3,5-Dimethyl-4-isoxazolecarboxylic acid

light beige powder

To a solution of ethyl 3, 5-dimethyl-4-isoxazolecarboxylate (2.4 g, 14 mmol) in THF (8 mL) and MeOH (8 mL) was added 5N aqueous NaOH (8.5 mL). The reaction was stirred at room temperature for 8 h. The reaction mixture was removed under reduced pressure and acidified with 6 N aqueous HCl to pH=2. The precipitated product was filtered, washed with water, and dried to afford 9 (2.1 g, 94.0percent) as a white solid.3, 5-Dimethyl-isoxazole-4-carboxylic acid [4-(4-benzhydryl-piperazin-1-yl)-3-fluoro-phenyl]-amide; To a mixture of 4-(4-benzhydryl-piperazin-1-yl)-3-fluoro-phenylamine (140 mg, 0.39 mmol) and triethylamine (0.103 mL, 1.96 eq) in DCE (10 mL) was added 3, 5-dimethyl-isoxazole-4-carbonyl chloride (75 mg, 1.2 eq, prepared from reaction of 600 mg (4.3 mmol) A mixture of To a solution of To a solution of

Molecular Weight:141.12
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:141.042593085
Monoisotopic Mass:141.042593085
Topological Polar Surface Area:63.3
Heavy Atom Count:10
Complexity:148
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes