Flupentixol dihydrochloride
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Flupentixol dihydrochloride
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CAS No:
2413-38-9
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Formula:
C23H25F3N2OS.2ClH
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Chemical Name:
Flupentixol dihydrochloride
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Synonyms:
1-Piperazineethanol,4-[3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-,hydrochloride (1:2);1-Piperazineethanol,4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]-,dihydrochloride;1-Piperazineethanol,4-[3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-,dihydrochloride;FX 703;Flupentixol dihydrochloride;Flupentixol hydrochloride;Emergil;Siplarol;Metamin
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CAS No:
Description
Flupentixol dihydrochloride, a thioxanthene drug, is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.
Characteristics
52.01000
6.08150
white or off-white solid
237-239 °C @ Solvent: Ethanol, Methanol
554.7ºC at 760 mmHg
289.3ºC
H2O: soluble
Desiccate at RT
3.87E-13mmHg at 25°C
LD50 oral in rat: 791mg/kg
Safety Information
UN 2811 6.1/PG 3
3
20/21/22
36/37/39
TL9900000
Xn
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 30 companies from 5 notifications to the ECHA C&L Inventory.
Flupentixol dihydrochloride Use and Manufacturing
Neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.
Computed Properties
Molecular Weight:507.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:506.1173245
Monoisotopic Mass:506.1173245
Topological Polar Surface Area:52
Heavy Atom Count:32
Complexity:592
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It is a thioxanthene derivative with a strong dopamine receptor blocking effect. In addition to blocking D1 and D2 receptors, it can also inhibit D2 autoreceptors and increase the DA concentration between synapses. It has no sedative effect. Its antipsychotic effect is 4 to 8 times stronger than that of Telden. In addition, it also has antidepressant and antianxiety effects.
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