4′-Hydroxychalcone
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4′-Hydroxychalcone
structure -
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CAS No:
2657-25-2
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Formula:
C15H12O2
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Chemical Name:
4′-Hydroxychalcone
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Synonyms:
2-Propen-1-one,1-(4-hydroxyphenyl)-3-phenyl-;Chalcone,4′-hydroxy-;1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one;4′-Hydroxychalcone;p-Cinnamoylphenol;4-Hydroxyphenyl styryl ketone;NSC 242264;1-(4-Hydroxyphenyl)-3-phenylpropenone;2098642-17-0
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CAS No:
Description
4'-Hydroxychalcone, a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3].
Characteristics
37.3
2.7
yellow-cream powder
1.191 g/cm3
171-172 °C @ Solvent: Ethanol
419.6°C at 760 mmHg
179.1ºC
1.653
1.23E-07mmHg at 25°C
Safety Information
36/37/38
37/39-26-37
Xi
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
Computed Properties
Molecular Weight:224.25
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:224.083729621
Monoisotopic Mass:224.083729621
Topological Polar Surface Area:37.3
Heavy Atom Count:17
Complexity:269
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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