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Flupentixol

Flupentixol structure

CAS No:
2709-56-0
Formula:
C23H25F3N2OS
Chemical Name:
Flupentixol
Synonyms:
1-Piperazineethanol,4-[3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-;1-Piperazineethanol,4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]-;9H-Thioxanthene,1-piperazineethanol deriv.;4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol;Fluxanxol;2-(Trifluoromethyl)-9-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propylidene]thiaxanthen;2-Trifluoromethyl-9-(3-[4-(2-hydroxyethyl)-1-piperazinyl]propylidene)thioxanthene;Fluanxol;Flupenthixol;Flupentixol;4-[3-[2-(Trifluoromethyl)thioxanthen-9-ylidene]propyl]-1-piperazineethanol;LC 44;N 7009;Siplaril
Categories:
Active Pharmaceutical Ingredients > Other Chemical Drugs

Description

ChEBI: A thioxanthene derivative having a trifluoromethyl substituent at the 2-position and a 3-(4-(2-hydroxyethyl)piperazin-1-yl)propylidene group at the 10-position with undefined double bond stereochemistry.

A thioxanthene neuroleptic that, unlike CHLORPROMAZINE, is claimed to have CNS-activating properties. It is used in the treatment of psychoses although not in excited or manic patients. (From Martindale, The Extra Pharmacopoeia, 30th ed, p595)

Flupentixol Basic Attributes

Molecular Weight：

434.51800

Exact Mass：

434.52

EC Number：

220-304-9

DSSTox ID：

DTXSID3058749

ATC Code：

N05AF01|N - Nervous system

Characteristics

PSA：

52.01000

XLogP3：

4.47750

Density：

1.306g/cm3

Boiling Point：

554.7ºC at 760mmHg

Flash Point：

289.3ºC

Refractive Index：

1.607

Collision Cross Section：

199.4 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Safety Information

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

R20/21/22

safety instructions：

36/37/39

RTECS Number：

TL9900000

Marks：

Xn: Harmful;

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

MeSH Entry Terms：

alpha-Flupenthixol

Flupentixol Use and Manufacturing

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:434.5
XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:434.16396908
Monoisotopic Mass:434.16396908
Topological Polar Surface Area:52
Heavy Atom Count:30
Complexity:592
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes