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Toxogonin

Toxogonin structure

CAS No:
114-90-9
Formula:
C14H16N4O3.2Cl
Chemical Name:
Toxogonin
Synonyms:
Pyridinium,1,1′-[oxybis(methylene)]bis[4-[(hydroxyimino)methyl]-,chloride (1:2);Pyridinium,1,1′-(oxydimethylene)bis[4-formyl-,dichloride,dioxime;Pyridinium,1,1′-[oxybis(methylene)]bis[4-[(hydroxyimino)methyl]-,dichloride;1,1′-(Oxydimethylene)bis[4-formylpyridinium chloride],dioxime;Obidoxime chloride;Toxogonin;LuH6;LuH6-Cl2;LueH 6;1,1′-(Oxydimethylene)bis[4-formylpyridinium] dichloride dioxime;Toxogonin dichloride;Bis(4-hydroxyiminomethylpyridiniummethyl) ether dichloride;Toksobidin;Toxobidin;Toxogonine;Obidoxime hydrochloride;Efosim;BH 6;144252-47-1
Categories:
Active Pharmaceutical Ingredients > Specialty Drugs

Description

Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated[1].

Cholinesterase reactivator occurring in two interchangeable isomeric forms, syn and anti.

Toxogonin Basic Attributes

Molecular Weight：

359.21

Exact Mass：

358.06000

EC Number：

204-059-5

Characteristics

PSA：

82.17000

Density：

1.33g/cm3

Melting Point：

220 °C

Boiling Point：

1132.2ºC at 760 mmHg

Flash Point：

638.5ºC

Refractive Index：

1.606

Storage Conditions：

-20°C Freezer

Toxicity：

Peritoneal-rat LD50: 189 mg/kg; oral-mouse LD50: 2240 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and bromide fumes

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

UU6825000

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. They are an important component of therapy in agricultural, industrial, and military poisonings by organophosphates and sulfonates. (See all compounds classified as Cholinesterase Reactivators.)

MeSH Entry Terms：

Chloride, Obidoxime

Toxogonin Use and Manufacturing

antibacterial

Computed Properties

Molecular Weight:359.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:358.0599458
Monoisotopic Mass:358.0599458
Topological Polar Surface Area:82.2
Heavy Atom Count:23
Complexity:303
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes