(R)-(+)-THALIDOMIDE
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(R)-(+)-THALIDOMIDE
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CAS No:
2614-06-4
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Formula:
C13H10N2O4
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Chemical Name:
(R)-(+)-THALIDOMIDE
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Synonyms:
(R)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3-(2H)-DIONE;R-(+)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE;(R)-(+)-THALIDOMIDE;6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2;6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid;(+)-2-[(R)-2,6-Dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione;(+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide;(3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione
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CAS No:
Description
(R)-Thalidomide ((R)-(+)-Thalidomide) is the R-enantiomer of Thalidomide. (R)-Thalidomide has sedative properties[1][2].
(R)-thalidomide is a 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has R-configuration at the chiral centre. It has a role as a sedative. It is an enantiomer of a (S)-thalidomide.
Needles
Characteristics
83.55000
0.35450
1.2944 (rough estimate)
269-271°C
401.48°C (rough estimate)
262.1ºC
1.5300 (estimate)
-20ºC Freezer
1.65E-10mmHg at 25°C
10.70±0.40(Predicted)
-20°C Freezer
Safety Information
NONH for all modes of transport
3
T
53-36/37/39-45
TI4925000
T: Toxic;
P201-P308 + P313
61-22
|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
(R)-(+)-THALIDOMIDE Use and Manufacturing
Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative
Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.
Computed Properties
Molecular Weight:258.23
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:258.06405680
Monoisotopic Mass:258.06405680
Topological Polar Surface Area:83.6
Heavy Atom Count:19
Complexity:449
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes