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Melengestrol acetate

Melengestrol acetate structure

CAS No:
2919-66-6
Formula:
C25H32O4
Chemical Name:
Melengestrol acetate
Synonyms:
Pregna-4,6-diene-3,20-dione,17-(acetyloxy)-6-methyl-16-methylene-;Pregna-4,6-diene-3,20-dione,17-hydroxy-6-methyl-16-methylene-,acetate;17-(Acetyloxy)-6-methyl-16-methylenepregna-4,6-diene-3,20-dione;BDH 1921;5373;NSC-70968;17α-Acetoxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione;6-Dehydro-16-methylene-17α-hydroxy-6α-methylprogesterone acetate;17-Hydroxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione acetate;Melengestrol acetate;MGA;6-Methyl-16-methylene-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate;17-Acetoxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione;MGA 100 (steroid);MGA 100;Heifermax 500;MGA 264
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Light Tan Solid

Melengestrol acetate is a corticosteroid hormone.|A 6-methyl progesterone acetate with reported glucocorticoid activity and effect on estrus.|Melengestrol Acetate is a progestogen-like compound used as a cattle feed additive for its growth promoting effects and suppression of estrus (heat) in heifers. Critics have claimed that hormones used as growth promotants in cattle may cause breast cancer. (NCI)|A 6-methyl PROGESTERONE acetate with reported glucocorticoid activity and effect on ESTRUS.

Melengestrol acetate Basic Attributes

Molecular Weight：

396.519

Exact Mass：

396.52

EC Number：

220-859-7

UNII：

4W5HDS3936

NSC Number：

70968

DSSTox ID：

DTXSID5048184

NCI Thesaurus Code：

C74577

HScode：

29372390

Characteristics

PSA：

60.44000

XLogP3：

4.21

Density：

1.1±0.1 g/cm3

Melting Point：

224-226 °C

Boiling Point：

516.1±50.0 °C at 760 mmHg

Flash Point：

221.7±30.2 °C

Refractive Index：

1.555

Toxicity：

LD50 (mg/kg): >8000 orally in rats; >2500 i.p. in mice (Zimbelman)

Collision Cross Section：

198.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|201.51 Å² [M+H]+

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R62

safety instructions：

RTECS Number：

TU4141000

Marks：

Xn: Harmful;

Precautionary statement(s)：

P280

Hazard Statements：

H361

GHS Classification：

|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

MeSH Entry Terms：

Acetate, Melengestrol

Melengestrol acetate Use and Manufacturing

Uses

antiarrhythmic, cardiotonic, hypertensive, Na/K ATPase inhibitor Orally active progestational steroid. Progestogen; growth promotant.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Pharmaceuticals

Food Additive Classes：

Veterinary Drug -> PRODUCTION_AID;

Computed Properties

Molecular Weight:396.5
XLogP3:3.1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:396.23005950
Monoisotopic Mass:396.23005950
Topological Polar Surface Area:60.4
Heavy Atom Count:29
Complexity:893
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Melengestrol acetate

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

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Melengestrol acetate CAS2919-66-6 Light yellow powder

CAS No.: 2919-66-6

Grade: Ingredients

Content: 99%

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