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Gossypol

Gossypol structure

CAS No:
303-45-7
Formula:
C30H30O8
Chemical Name:
Gossypol
Synonyms:
[2,2′-Binaphthalene]-8,8′-dicarboxaldehyde,1,1′,6,6′,7,7′-hexahydroxy-3,3′-dimethyl-5,5′-bis(1-methylethyl)-;[2,2′-Binaphthalene]-8,8′-dicarboxaldehyde,1,1′,6,6′,7,7′-hexahydroxy-5,5′-diisopropyl-3,3′-dimethyl-;1,1′,6,6′,7,7′-Hexahydroxy-3,3′-dimethyl-5,5′-bis(1-methylethyl)[2,2′-binaphthalene]-8,8′-dicarboxaldehyde;2,2′-Bis[8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthyl];2,2′-Bis[1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthyl];Gossypol;1,1′,6,6′,7,7′-Hexahydroxy-5,5′-diisopropyl-3,3′-dimethyl-2,2′-binaphthalene-8,8′-dicarboxaldehyde;1,1′,6,6′,7,7′-Hexahydroxy-3,3′-dimethyl-5,5′-diisopropyl-2,2′-binaphthyl-8,8′-dialdehyde;1,1′,6,6′,7,7′-Hexahydroxy-3,3′-dimethyl-5,5′-diisopropyl[2,2′-binaphthalene]-8,8′-dicarboxaldehyde;Tash 1;(±)-Gossypol;Pogosin;No Fertil;NSC 56817;NSC 624336;1,6,7,1′,6′,7′-Hexahydroxy-5,5′-diisopropyl-3,3′-dimethyl-[2,2′]binaphthalenyl-8,8′-dicarboxaldehyde;BL 193;40112-23-0;732279-01-5
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Gossypol, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

Gossypol Basic Attributes

Molecular Weight：

518.55

Exact Mass：

518.55

EC Number：

1806241-263-5

HScode：

29124990

Characteristics

PSA：

156

XLogP3：

8.22 (est)

Appearance：

Solid

Density：

1.4±0.1 g/cm3

Melting Point：

199 °C

Boiling Point：

707.9±55.0 °C at 760 mmHg

Flash Point：

395.9±28.0 °C

Refractive Index：

1.742

Water Solubility：

soluble in 100%ethanol (25 mg/ml), DMF (25 mg/ml), acetone, DMSO (25 mM), methanol (2 mg/ml), ether, chloroform, sodium carbonate, and dilute aqueous solutions of ammonia . Insoluble in water. Gossypol is a male antifertility agent with antispermatogenic activity and has been shown to contain antitumor, anitviral, and antioxidant properties.

Storage Conditions：

2-8°C

Vapor Pressure：

7.06X10-21 mm Hg at 25 deg C (est)

Toxicity：

Oral-Rat LD50: 325 mg/kg; Oral-Mouse LD50: 765 mg/m3/4 hours

Flammability characteristics：

Flammable, spicy and irritating smoke emitted from the fire

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-40-36/37/38

safety instructions：

22-36-36/37/39-27-26

RTECS Number：

DU3100000

Marks：

Xn,Xi

Storage features：

Treasury is low temperature, ventilated, dry; stored separately from food raw materials

Precautionary statement(s)：

P281

Hazard Statements：

H351

Toxicity

Toxicity class：

highly toxic

Gossypol Use and Manufacturing

Gossypol is a mixture of natural polyphenols isolated from the cotton plant. It causes spermatogenesis arrest in humans and also functions as an anti-malarial agent. Antiinflammatory. Anticancer.

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