5-Fluorouridine
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5-Fluorouridine
structure -
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CAS No:
316-46-1
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Formula:
C9H11FN2O6
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Chemical Name:
5-Fluorouridine
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Synonyms:
Uridine,5-fluoro-;5-Fluorouridine;NSC 146604;NSC 519273;14807-85-3
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CAS No:
Description
5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity[1][2][3][4]. 5-fluorouridine inhibits rRNA synthesis of human colon carcinoma cells[3]. 5-Fluorouridine exhibits cytotoxic effect on growth of L1210 cells with an IC50 of 2 nM[4].
5-fluorouridine is an organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring. It has a role as a mutagen. It is an organofluorine compound and a member of uridines.|5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine base attached to a sugar. 5-fluorouridine is known to target uridine phosphorylase. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.
Characteristics
119
-1.7
White Powder
1.8±0.1 g/cm3
151-152 °C
1.641
H2O: soluble
2-8°C
17 º (c=2, water 25 ºC)
Safety Information
NONH for all modes of transport
3
40-68-36/37/38
22-26-36/37-36/37/39-27-24/25
YU8050000
Xn,Xi
Harmful
Stable under normal temperatures and pressures.
P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, P501
H302
Computed Properties
Molecular Weight:262.19
XLogP3:-1.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:262.06011424
Monoisotopic Mass:262.06011424
Topological Polar Surface Area:119
Heavy Atom Count:18
Complexity:414
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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