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(-)-Reserpine

(-)-Reserpine structure

CAS No:
50-55-5
Formula:
C33H40N2O9
Chemical Name:
(-)-Reserpine
Synonyms:
Yohimban-16-carboxylic acid,11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-,methyl ester,(3β,16β,17α,18β,20α)-;3β,20α-Yohimban-16β-carboxylic acid,18β-hydroxy-11,17α-dimethoxy- methyl ester 3,4,5-trimethoxybenzoate (ester);3β,20α-Yohimban-16β-carboxylic acid,18β-hydroxy-11,17α-dimethoxy-,methyl ester,3,4,5-trimethoxybenzoate;Benz[g]indolo[2,3-a]quinolizine,yohimban-16-carboxylic acid deriv.;Anquil;Banasil;Bioserpine;Crystoserpine;Elserpine;Eserpine;Eskaserp;Kitine;Lemiserp;Loweserp;Mayserpine;Reserpic acid methyl ester 3,4,5-trimethoxybenzoate (ester);Methyl reserpate 3,4,5-trimethoxybenzoate (ester);Quiescin;Raucap;Raulen;Raurine;Rau-sed;Rausedil;Rausedyl;Rausingle;Resercen;Reserpamed;Reserpex;Reserpine;Reserpoid;Resine;Respital;Restran;Riserpa;Rivasin;Roxinoid;Sandril;Sedaraupin;Serfin;Serolfia;T-Serp;Serpaloid;Serpanray;Serpasil;Serpate;Serpen;Serpentina;Serpicon;Serpiloid;Sertabs;Sertina;3,4,5-Trimethoxybenzoyl methyl reserpate;Vio-Serpine;Raupasil;Serpine (pharmaceutical);ENT 50146;Serpasil premix;Raunervil;Reserlor;Sedserp;Serpipur;Temposerpine;Serp-AFD;Resercaps;Reserpil;Triserpin;Rauwasedin;Apoplon;Serpasol;Serpine;Carpacil;Hiposerpil;Deserpine;11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester;(-)-Reserpine;Serpasil Serpasol;NSC 237659;NSC 59272;1407-38-1;8048-25-7;141099-49-2;873409-80-4;909883-12-1;911481-85-1
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

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Description

Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).

(-)-Reserpine Basic Attributes

Molecular Weight：

608.68

Exact Mass：

608.68

BRN：

102014

EC Number：

200-047-9

HScode：

3003909090

Characteristics

PSA：

118

XLogP3：

3.2

Appearance：

Reserpine appears as white or cream to slightly yellow crystals or crystalline powder. Odorless with a bitter taste. (NTP, 1992)

Density：

1.3±0.1 g/cm3

Melting Point：

264.5 °C

Boiling Point：

700.1±60.0 °C at 760 mmHg

Flash Point：

22℃

Refractive Index：

177 ° (C=1, DMF)

Water Solubility：

soluble in water.

Storage Conditions：

2-8°C

Toxicity：

LD50 oral in rat: 420mg/kg

Specific rotation：

D23 -118° (CHCl3); D26 -164° (c = 0.96 in pyridine); D26 -168° (c = 0.624 in DMF)

Odor：

Odorless

PKA：

6.6None

Safety Information

Packing level：

Transport codes：

3077

wgk germany：

hazard class code：

22-67-36-10

safety instructions：

22-36/37/39-26

RTECS Number：

ZG0350000

Marks：

Xn,Xi

Stability/Shelf Life：

Stable, but darkens slowly in light. Combustible. Incompatible with strong acids, reducing agents, oxidizing agents.

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

(-)-Reserpine Use and Manufacturing

An inhibitor of transport of biogenic amines into adrenal chromaffin granules

Computed Properties

Molecular Weight:608.7
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:10
Exact Mass:608.27338086
Monoisotopic Mass:608.27338086
Topological Polar Surface Area:118
Heavy Atom Count:44
Complexity:1000
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Acetic acid

Pectin

Drug Function and Efficacy

Adrenergic neurosuppressants can block the storage of mediators in adrenergic nerve endings and deplete the mediators with pressor effects in the vesicles.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Reserpine Tablets
Ingredients	This product is a compound preparation, and its components are: each tablet contains 0.032 mg of reserpine, 3.1 mg of hydrochlorothiazide, 1.0 mg of vitamin B6, 1.0 mg of calcium pantothenate, 30 mg of magnesium trisilicate, 30 mg of potassium chloride, 1.0 mg of vitamin B1, 4.2 mg of dihydralazine sulfate, and 2.1 mg of promethazine hydrochloride.
Indication	Patients taking reserpine should be careful because the addition of digitalis may cause sudden cardiac arrest or arrhythmia.
Specifications	Compound
Manufacturer	Hefei Limin Pharmaceutical Co., Ltd.

Compound Reserpine Tablets
Ingredients	This product is a compound preparation, and its components are: each tablet contains 0.032 mg of reserpine, 3.1 mg of hydrochlorothiazide, 1.0 mg of vitamin B6, 1.0 mg of calcium pantothenate, 30 mg of magnesium trisilicate, 30 mg of potassium chloride, 1.0 mg of vitamin B1, 4.2 mg of dihydralazine sulfate, and 2.1 mg of promethazine hydrochloride.
Indication	Patients taking reserpine should be careful because the addition of digitalis may cause sudden cardiac arrest or arrhythmia.
Specifications	Compound
Manufacturer	China Resources Double-Crane Pharmaceutical Co., Ltd.

Reserpine Tablets
Ingredients	The main ingredient and chemical name of this product are: 11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohen-16-carboxylic acid methyl ester
Indication	When used in combination with ethanol or CNS depressants, the central nervous system inhibitory effect may be aggravated; 1 When used in combination with other antihypertensive drugs or diuretics, the antihypertensive effect may be enhanced, and dosage adjustment is required; when used in combination with beta-blockers, the latter's effect may be enhanced; 2 When used in combination with digitalis or quinidine, large doses may cause arrhythmias; 3 When used in combination with levodopa, dopamine may be depleted, leading to Parkinson's disease; 4 When used in combination with indirect adrenergic drugs such as ephedrine and amphetamine, catecholamine storage may be depleted, inhibiting the effect of adrenergic drugs; 5 When used in combination with direct adrenergic drugs such as epinephrine, isoproterenol, norepinephrine, metaraminol, and phenylephrine,
Specifications	0.25mg

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Registered Holders

INDENA SPA

France
Active
Qitong Pharmaceutical Technology Consulting (Shanghai) Co., Ltd.

China
Active
Indena BIOTECHNOLOGY (SHANGHAI) Co., Ltd.

China
Active

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