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(±)-Chloroquine diphosphate

(±)-Chloroquine diphosphate structure

CAS No:
50-63-5
Formula:
C18H26ClN3.2H3O4P
Chemical Name:
(±)-Chloroquine diphosphate
Synonyms:
1,4-Pentanediamine,N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-,phosphate (1:2);Quinoline,7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-,phosphate (1:2);Quinoline,7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-,diphosphate;3377RP;SN 7618;Aralen diphosphate;Aralen phosphate;Avloclor;Bemaphate;7-Chloro-4-[(4′-diethylamino-1-methylbutyl)amino]quinoline diphosphate;Chloroquin diphosphate;Chloroquine diphosphate;Chloroquine phosphate;Nivaquine B;Resoquine;Sanoquin;Tanakan;Arechin;Resochin;Delagil;Quingamine;Chingamin;Chingamin phosphate;Gontochin phosphate;Khingamin;Chlorochin diphosphate;WR 1522;Chloroquine dihydrogen phosphate (1:2);Tanakan (antimalarial);(±)-Chloroquine diphosphate;dl-Chloroquine diphosphate;NSC 14050;Tresochin;Imagon;Malaquin;Alexoquine;Cidoquine;Maladrin;Quivaclor;6384-82-3;69698-56-2
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

Chloroquine (diphosphate) is an antimalarial and anti-inflammatory drug widely used to treat malaria and rheumatoid arthritis. Chloroquine is an inhibitor of autophagy and toll-like receptors (TLRs).

(±)-Chloroquine diphosphate Basic Attributes

Molecular Weight：

515.86

Exact Mass：

515.135315

EC Number：

200-055-2

DSSTox ID：

DTXSID7044681

HScode：

2933499090

Characteristics

PSA：

184

XLogP3：

3.02640

Appearance：

solid

Melting Point：

193-195 °C

Boiling Point：

189-193 °C @ Press: 0.2-0.3 Torr

Flash Point：

232.3ºC

Water Solubility：

soluble in water;H2O: 50 mg/mL, clear

Storage Conditions：

Desiccate at RT

Vapor Pressure：

5.0X10-9 mm Hg at 25 deg C (est)

Toxicity：

LD50 oral in rat: 623mg/kg

Collision Cross Section：

175.6 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

1544

wgk germany：

hazard class code：

22-40-20/21/22

safety instructions：

22-24/25-36

RTECS Number：

VB2450000

Marks：

Stability/Shelf Life：

SENSITIVE TO LIGHT. /SULFATE/

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (98.68%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P281, P301+P312, P308+P313, P314, P330, P405, and P501|Aggregated GHS information provided by 76 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)|Pharmacological agents destructive to nematodes in the superfamily Filarioidea. (See all compounds classified as Filaricides.)

MeSH Entry Terms：

arechin

(±)-Chloroquine diphosphate Use and Manufacturing

Uses

An antimalarial compound.Anti-malarial drugs and anti-amebic drugs, used to control malaria symptoms, preventive prevention of malaria symptoms and amoebic liver abscess, etc.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:515.9
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:8
Exact Mass:515.1353167
Monoisotopic Mass:515.1353167
Topological Polar Surface Area:184
Heavy Atom Count:32
Complexity:359
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Chloroquine phosphate
Manufacturer	Chongqing Southwest NO.2 Pharmaceutical FACTORY Co., Ltd.

Compound Dibazole Hydrochlorothiazide Capsules
Ingredients	Dibazole, promethazine hydrochloride, chloroquine phosphate, guanidine sulfate, vitamin B6, potassium chloride, reserpine, chlordiazepoxide, hydrochlorothiazide, calcium lactate, vitamin B1, magnesium trisilicate.
Specifications	Compound
Manufacturer	Shaanxi Bai LU Pharmaceutical Co., Ltd.

Chloroquine phosphate
Specifications	API

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Registered Holders

SUVEN PHARMACEUTICALS LTD

United States
Active
NATCO PHARMA LTD

Brazil
Active
IPCA LABORATORIES LIMITED

Brazil
Active

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Guide of (±)-Chloroquine diphosphate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

(±)-Chloroquine diphosphate

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