1,3-Difluoro-2-methoxy-5-nitrobenzene

Step 2. Preparation of Into a 250-mL round-bottom flask, was placed l, 3-difluoro-2-methoxy-5- nitrobenzene (1 g, 5.29 mmol, 1 equiv), 3-(pyrrolidin-l-yl)propan-l-ol (683 mg, 5.29 mmol, 1 equiv), t-BuOK (10.6 mL, 2.00 equiv), tetrahydrofuran (15 mL). The resulting solution was stirred for 1 h at 0 °C in a water/ice bath. The resulting mixture was concentrated under vacuum. The crude product (5 mL) was purified by ACN/H20(l/l).This resulted in 550mg (35percent) of as a yellow solid. Analytical Data: LC-MS: (ES, m/z): RT = 0.986min, LCMS 53: m/z = 299 [M+l]. Ti NMR (400 MHz, Methanol-d4) delta 7.75 (s, 1H), 7.73 (s, 1H), 4.28 - 4.25 (m, 2H), 4.03 - 3.99 (m, 6H), 2.78 - 2.66 (m, 2H), 2.65 - 2.62 (m, 2H), 2.03 - 1.99 (s, 3H), 1.88 - 1.85 (m, 2H).

Molecular Weight:189.12
XLogP3:1.9
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:189.02374935
Monoisotopic Mass:189.02374935
Topological Polar Surface Area:55
Heavy Atom Count:13
Complexity:185
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes