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1-Fluoro-2-iodobenzene

1-Fluoro-2-iodobenzene structure

CAS No:
348-52-7
Formula:
C6H4FI
Chemical Name:
1-Fluoro-2-iodobenzene
Synonyms:
Benzene,1-fluoro-2-iodo-;1-Fluoro-2-iodobenzene;o-Fluoroiodobenzene;o-Iodofluorobenzene;o-Fluorophenyl iodide;2-Fluoroiodobenzene;1-Iodo-2-fluorobenzene;2-Iodofluorobenzene;2-Fluorophenyl iodide;NSC 51766;1-Fluoro-2-iodo-5-trifluoromethylbenzene;2-Iodo-1-fluorobenzene;2-Fluoro-1-iodobenzene
Categories:
Organic Chemistry > Hydrocarbons and Derivatives

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Description

Clear colourless to light yellow liquid

1-Fluoro-2-iodobenzene Basic Attributes

Molecular Weight：

222

Exact Mass：

222.00

BRN：

2039770

EC Number：

206-477-3

NSC Number：

51766

DSSTox ID：

DTXSID3059842

HScode：

2903999090

Characteristics

PSA：

XLogP3：

3.1

Appearance：

Clear light yellow Liquid

Density：

1.9206 g/cm³ @ Temp: 25.00 °C

Melting Point：

-41.5 °C

Boiling Point：

188.6 °C

Flash Point：

160 °F

Refractive Index：

1.592

Storage Conditions：

Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.

Safety Information

Packing level：

Ⅲ

Hazard category：

IRRITANT

Transport codes：

UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous substances, liquid, n.o.s. HI: all (not BR)

wgk germany：

hazard class code：

22-37/38-41-51/53-36/37/38

safety instructions：

26-39-61-37/39

Marks：

Xn,N,Xi

Hazard note：

Irritant

Stability/Shelf Life：

Stable at room temperature in closed containers under normal storage and handling conditions. May discolor on exposure to light.

Precautionary statement(s)：

P280-P305 + P351 + P338

Hazard Statements：

H302-H315-H318

1-Fluoro-2-iodobenzene Use and Manufacturing

Methods of Manufacturing

General procedure: To a 15 mL test tube with septum Cs2CO3 (0.6 mmol, 195 mg), aromaticcarboxylic acid (1) (0.3 mmol), [Ir(dF(CF3)ppy)2dtbbpy]PF6 (D) (6 μmmol, 6.7 mg), Niodosuccinimide(NIS) (0.9 mmol, 202.5 mg) and I2 (15 μmol, 5 molpercent) were added. The tube was evacuated and backfilled with argon for three times, and then 3 mL of dry 1, 2-dichloroethane(DCE) was added through a syringer under argon. The tube was sealed with Parafilm M® andplaced in an oil bath with a contact thermometer, and the reaction was carried out at 50 °C underirradiation with 6 × 5 W blue LEDs (λmax = 455 nm). After 24 or 36 h, the resulting mixture wasfiltered through a 2 cm thick pad of silica, and the silica was washed with dichloromethane (DCM)(50 mL). The filtrate was collected and the solvent was removed in vacuo. The crude residue waspurified by silica gel flash column chromatography to provide the target product (2). (Note: Thereaction was very sensitive to moisture, and the yields sharply decreased to less than 5percent when0.01 equivalent of H2O was added to the reaction system).

Uses

suzuki reaction

Manufacturing Info：

Benzene, 1-fluoro-2-iodo-: ACTIVE

Computed Properties

Molecular Weight:222.00
XLogP3:3.1
Hydrogen Bond Acceptor Count:1
Exact Mass:221.93418
Monoisotopic Mass:221.93418
Heavy Atom Count:8
Complexity:74.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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1-Fluoro-2-iodobenzene

CAS No.: 348-52-7

Content: 99.00%

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Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
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1-Fluoro-2-iodobenzene 99% Liquid

CAS No.: 348-52-7

Content: 99%

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