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2-Fluoroaniline

2-Fluoroaniline structure

CAS No:
348-54-9
Formula:
C6H6FN
Chemical Name:
2-Fluoroaniline
Synonyms:
Benzenamine,2-fluoro-;Aniline,o-fluoro-;2-Fluorobenzenamine;o-Fluoroaniline;2-Fluoroaniline;1-Amino-2-fluorobenzene;2-Fluorophenylamine;NSC 10299
Categories:
Organic Chemistry > Organic Fluorine Compound

Description

Clear colorless to brown liquid

2-fluoroaniline is a clear liquid with a mild sweet odor. Sinks in and mixes slowly with water. (USCG, 1999)

2-fluoroaniline is a clear liquid with a mild sweet odor. Sinks in and mixes slowly with water. (USCG, 1999)|2-fluoroaniline is a derivative of aniline in which the hydrogen at position 2 has been substituted by fluorine. It is used as a pharmaceutical intermediate It is a primary arylamine and a fluoroaniline.

2-Fluoroaniline Basic Attributes

Molecular Weight：

111.12

Exact Mass：

111.12

BRN：

1524219

EC Number：

206-478-9

UNII：

SE32ZK6617

NSC Number：

10299

UN Number：

2941

DSSTox ID：

DTXSID8059843

HScode：

29214210

Characteristics

PSA：

XLogP3：

1.26

Appearance：

Clear colorless Liquid

Density：

1.1476 g/cm³ @ Temp: 25.00 °C

Melting Point：

-34.6 °C

Boiling Point：

175 °C

Flash Point：

140 °F

Refractive Index：

1.548

Water Solubility：

17 g/L (20°C)

Storage Conditions：

2-8°C

Vapor Pressure：

1 hPa (20 °C)

PKA：

3.2(at 25 °C)

Dissociation Constants：

3.2 (at 25 °C)

Air and Water Reactions：

Water soluble.

Reactive Group：

Aryl Halides

Reactivity Profile：

2-FLUOROANILINE is a base. Neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

UN 2941 6.1/PG 3

wgk germany：

hazard class code：

22-37/38-41-36/38-33-23/24/25

safety instructions：

26-39-37/39-45-36/37-28

RTECS Number：

BY1390000

Marks：

Xn,T,Xi

Hazard note：

Toxic/Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P370+P378, P391, P403+P233, P403+P235, P405, P501

Hazard Statements：

H226

Fire Hazards：

Special Hazards of Combustion Products: Irritating and toxic hydrogen fluoride and oxides of nitrogen may form in fires. (USCG, 1999)

Fire Fighting：

Fire Extinguishing Agents: Water, dry chemical, foam or carbon dioxide (USCG, 1999)

Isolation and Evacuation：

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Nonfire Spill Response：

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Personal Protective Equipment：

Rubber gloves; chemical goggles; protective clothing; approved respirator. (USCG, 1999)

Drug Information

Health Hazards：

Inhalation or ingestion causes bluish tint to fingernails, lips and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation. (USCG, 1999)

First Aid：

INHALATION: Remove victim from exposure immediately; if needed, administer oxygen; refer to physician. EYES: Flush with water for at least 15 min. SKIN: Remove victim from exposure immediately; remove contaminated clothing; wash contacted area with copious amounts of water and soap; if needed, administer oxygen; refer to physician. INGESTION: Induce vomiting; get medical attention. (USCG, 1999)

MeSH Entry Terms：

2-fluoroaniline

2-Fluoroaniline Use and Manufacturing

Uses

Used as medicine, pesticide and dye intermediate

Manufacturing Info：

Benzenamine, 2-fluoro-: ACTIVE

Computed Properties

Molecular Weight:111.12
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:111.048427358
Monoisotopic Mass:111.048427358
Topological Polar Surface Area:26
Heavy Atom Count:8
Complexity:74.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Hydrogen

2-Fluorobenzoic acid

Potassium fluoride

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