 Home > Encyclopedia > 1-Cyclopropylpiperazine

1-Cyclopropylpiperazine

1-Cyclopropylpiperazine structure

CAS No:
20327-23-5
Formula:
C7H14N2
Chemical Name:
1-Cyclopropylpiperazine
Synonyms:
Cyclopropylpiperazine;N-cyclopropylpiperazine;1-Cyclopropylpiperazine;Piperazine,1-cyclopropyl-;(Piperazin-1-yl)cyclopropane
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Request for Quotation

1-Cyclopropylpiperazine Basic Attributes

Molecular Weight：

126.2

Exact Mass：

126.115700

EC Number：

1312995-182-4

DSSTox ID：

DTXSID20406303

HScode：

2933599090

Characteristics

PSA：

15.3

XLogP3：

0.2

Density：

1.0±0.1 g/cm3

Boiling Point：

43°C/7mm

Flash Point：

89.2±9.4 °C

Refractive Index：

1.4804

Safety Information

Packing level：

Ⅲ

Hazard category：

Transport codes：

3267

Marks：

Precautionary statement(s)：

P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

1-Cyclopropylpiperazine Use and Manufacturing

A solution of tert-butyl 4-cyclopropylpiperazine-1-carboxylate (0.792 g, 3.50 mmol) in 4M HCl in 1, 4-dioxane (4.37 mL, 17.50 mmol) was stirred at room temperature for 3 h under nitrogen. The reaction mixture was filtered and washed with ether to afford crude 1-cyclopropylpiperazine (0.659 g) as a white solid. The crude product was purified by ion exchange chromatography, using a SCX column. The desired product was eluted from the column using 3.5M NH3/MeOH and pure fractions were evaporated to dryness to afford 1-cyclopropylpiperazine (0.264 g, 59.7percent) as a yellow oil. 1H NMR (399.9 MHz, DMSO-d6) δ 0.25-0.30 (2H, m), 0.35-0.40 (2H, m), 1.54-1.60 (1H, m), 2.43 (4H, t), 2.60-2.65 (4H, t), 3.30 (1H, s)

Computed Properties

Molecular Weight:126.20
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:126.115698455
Monoisotopic Mass:126.115698455
Topological Polar Surface Area:15.3
Heavy Atom Count:9
Complexity:93.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 1-Cyclopropylpiperazine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

1-Cyclopropylpiperazine

CAS No.: 20327-23-5

Content: 99.00%

Inquiry
Greenbo Biochem Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED Intermediates

1-Cyclopropylpiperazine 99% powder Professional Piperaizine seires Producer Greenbo

CAS No.: 20327-23-5

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hangzhou Chungyo Chemicals Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals

1-Cyclopropylpiperazine

CAS No.: 20327-23-5

Grade: pharmaceutical grade

Inquiry
Sichuan Hengkang Contact Supplier

CN
5 YRS

Business licensed

Distributor Supplier of (S)-1-Boc-3-hydroxypiperidine,L-serine benzyl ester hydrochloride,(R)-1-Boc-3-hydroxymethylpiperazine,(R)-(+)-2-Tetrahydrofuroic acid

1-Cyclopropylpiperazine 98% light yellow liquid

CAS No.: 20327-23-5

Grade: Pharmaceutical Grade

Content: 98%

Inquiry
Prisun Pharmatech Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed

Distributor Supplier of Pharmaceutical

1-cyclopropylpiperazine 99%

CAS No.: 20327-23-5

Inquiry