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Naftidrofuryl oxalate

Naftidrofuryl oxalate structure

CAS No:
3200-06-4
Formula:
C24H33NO3.C2H2O4
Chemical Name:
Naftidrofuryl oxalate
Synonyms:
2-Furanpropanoic acid,tetrahydro-α-(1-naphthalenylmethyl)-,2-(diethylamino)ethyl ester,ethanedioate (1:1);2-Furanpropionic acid,tetrahydro-α-(1-naphthylmethyl)-,2-(diethylamino)ethyl ester oxalate (1:1);Nafronyl oxalate;Naftidrofuryl oxalate;Praxilene;LS 121;Dusodril;Dubimax;EU 1806;Iridus;Naphtidrofuryl oxalate;Di-Actane;Citoxid;Nafronyl acid oxalate;NSC 225233;26263-44-5
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Naftidrofuryl is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.Target: 5-HT2 receptorNaftidrofuryl may be effective for relieving the pain of muscle cramps.[1]Naftidrofuryl oxalate is the only vasoactive drug for peripheral arterial disease (PAD) which is likely to be cost-effective.[2]Naftidrofuryl oxalate is ranked first for both maximum walking distance (MWD

A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.

Naftidrofuryl oxalate Basic Attributes

Molecular Weight：

473.56

Exact Mass：

473.24100

EC Number：

221-703-0

UNII：

5ADB8D9388

NSC Number：

758462|225233

DSSTox ID：

DTXSID6045533

HScode：

29321900

Characteristics

PSA：

113.37000

XLogP3：

3.60820

Density：

1.2205 (rough estimate)

Melting Point：

110-111 °C

Boiling Point：

574°C (rough estimate)

Refractive Index：

1.6000 (estimate)

Toxicity：

LD50 oral in rat: 711mg/kg

Collision Cross Section：

189.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

LU5805000

Marks：

Xn,Xi

Precautionary statement(s)：

P280

Hazard Statements：

H302 + H312

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 42 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

Artocoron

Naftidrofuryl oxalate Use and Manufacturing

antineoplastic

Computed Properties

Molecular Weight:473.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:12
Exact Mass:473.24135246
Monoisotopic Mass:473.24135246
Topological Polar Surface Area:113
Heavy Atom Count:34
Complexity:536
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Toluene

Potassium hydroxide

Sodium hydroxide

Oxalic acid

Ethanol

Isopropanol

Acetone

Hydrochloric acid

Thionyl chloride