2-Propylpiperidine
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2-Propylpiperidine
structure -
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CAS No:
3238-60-6
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Formula:
C8H17N
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Chemical Name:
2-Propylpiperidine
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Synonyms:
Piperidine,2-propyl-;Piperidine,2-propyl-,(±)-;Coniine,DL-;2-Propylpiperidine;dl-Coniine;(±)-Coniine;10388-95-1
- Categories:
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CAS No:
Description
Colorless liquid; darkens on exposure tolight and air; polymerizes; boils at 166°C(330.8°F); melts at -2°C (28.4°F); alkaline, pKa 3.1; density 0.845 at 20°C (68°F);slightly soluble in water and chloroform,readily soluble in most organic solvents.
Liquid
2-Propylpiperidine Basic Attributes
127.23
127.23
221-801-3
DTXSID3046821
COLORLESS LIQUID
2933399090
Characteristics
12
2.25740
clear colorless to yellow-green liquid
0.844-0.848 @ 20 DEG C/4 DEG C
98-100 °C @ Solvent: Diethyl ether
56-60 °C @ Press: 13 Torr
48.4ºC
1.429
18 mg/mL
2-8°C
MOUSY ODOR
ALKALINE
PK 3.1; K 7.5X10-4
VOLATILE WITH STEAM
Safety Information
IRRITANT
UN 2810 6.1/PG 2
3
23/24/25-40
22-36/37/39-45
T
P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P281, P301+P310, P302+P352, P303+P361+P353, P304+P340, P308+P313, P311, P312, P321, P322, P330, P361, P363, P370+P378, P403+P233, P403+P235, P405, P501
H226
|Danger|H226 (97.44%): Flammable liquid and vapor [Warning Flammable liquids]|P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P281, P301+P310, P302+P352, P303+P361+P353, P304+P340, P308+P313, P311, P312, P321, P322, P330, P361, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Toxicity
/CONINE/ IS THE EXTREMELY POISONOUS ALKALOID...WHICH MAY BE PRESENT TO THE EXTENT OF 2% IN THE LEAVES AND UNRIPE FRUITS /OF CONIUM MACULATUM, POISON HEMLOCK/.
Drug Information
6. 6= SUPER TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) LESS THAN 5 MG/KG; A TASTE (LESS THAN 7 DROPS) FOR 70 KG PERSON (150 LB).
CONINE HAS A NICOTINE-LIKE ACTION IN FIRST STIMULATING AND THEN DEPRESSING AUTONOMIC GANGLIA, AND A CURARE-LIKE EFFECT IN PARALYSING THE MOTOR NERVE ENDINGS TO THE SKELETAL MUSCLES.
DEATH OCCURS RAPIDLY (LESS THAN 3 HR) WITH THE MOST PROMINENT SIGNS AND SYMPTOMS REFERABLE TO PERIPHERAL PARALYSIS AND LOSS OF SENSATION. SYMPTOMS INCLUDE DROWSINESS, PARESTHESIAS, WEAKNESS, ATAXIA, NAUSEA, PROFUSE SALIVATION AND BRADYCARDIA FOLLOWED BY TACHYCARDIA. DEATH IS DUE TO RESPIRATORY ARREST FROM PARALYSIS OF RESPIRATORY MUSCLES, ALTHOUGH CENTRAL DEPRESSION MAY PLAY A ROLE AFTER VERY LARGE DOSES.|THE ALKALOIDS.../INCL/ CONIINE (FROM CONIUM MACULATUM, THE SPOTTED HEMLOCK) HAVE THE SAME ACTION AS NICOTINE.
cicutine
2-Propylpiperidine Use and Manufacturing
Coniine is present in all parts of the plantpoison hemlock (Conium maculatum). It isthe first alkaloid to be synthesized and structure determined. Because of its high toxicity,its clinical application is very limited.
Computed Properties
Molecular Weight:127.23
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:127.136099547
Monoisotopic Mass:127.136099547
Topological Polar Surface Area:12
Heavy Atom Count:9
Complexity:71
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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