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2-Ethylhexyl salicylate

2-Ethylhexyl salicylate structure

CAS No:
118-60-5
Formula:
C15H22O3
Chemical Name:
2-Ethylhexyl salicylate
Synonyms:
Benzoic acid,2-hydroxy-,2-ethylhexyl ester;Salicylic acid,2-ethylhexyl ester;WMO;Sunarome WMO;Sunarome O;2-Ethylhexyl salicylate;Octyl salicylate;2-Ethylhexyl o-hydroxybenzoate;Escalol 587;Octisalate;Uvinul 0-18;Neo Heliopan OS;NSC 46151;Dermoblock OS;Eusolex OS;Parsol EHS;Solarom OS;HallBrite OS-USP;2-Ethylhexyl 2-hydroxybenzoate;Ethylhexyl salicylate;EH-OB;8014-40-2;194304-34-2
Categories:
Cosmetic Ingredient > Light Stabilizer

Description

Octisalate is an organic compound used as an ingredient in sunscreens and cosmetics to absorb the full range of UVB rays from the sun.

Liquid

Ethylhexyl salicylate is a benzoate ester and a member of phenols. It derives from a salicylic acid.|Also known as Ethylhexyl Salicylate. Octyl salicylate is an oil soluble chemical sunscreen agent that absorbs UVB radiation. It does not protect against UVA. Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicylates are weak UVB absorbers and they are generally used in combination with other UV filters. Octyl salicylate appears to have a good safety profile. It covers wavelength in the range 295-315 nm, peak at 307-310 nm. It is an ester of salicylic acid and 2-ethylhexanol. The salicylate portion of the molecule absorbs ultraviolet light to protect skin from the harmful effects of exposure to sunlight, while the ethylhexanol portion functions as an emollient.

2-Ethylhexyl salicylate Basic Attributes

Molecular Weight：

250.33

Exact Mass：

250.33

EC Number：

204-263-4

NSC Number：

46151

DSSTox ID：

DTXSID7040734

HScode：

2918230000

Characteristics

PSA：

46.53000

XLogP3：

5.77

Appearance：

Liquid

Density：

1.0±0.1 g/cm3

Boiling Point：

189-190 °C21 mm Hg(lit.)

Flash Point：

>230 °F

Refractive Index：

1.510

Vapor Pressure：

8.07E-05mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36/37/39

RTECS Number：

VO3150000

Precautionary statement(s)：

P264, P280, P302+P352, P321, P332+P313, P362

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (99.93%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P321, P332+P313, and P362|Aggregated GHS information provided by 1532 companies from 6 notifications to the ECHA C&L Inventory.

Toxicity

Toxicity Summary：

LD50, (oral, rat): > 5000 mg/Kg. LD50 (dermal, rabbit): > 5000 mg/Kg.

Protein Binding：

Intended for local use only, no systemic absorption.

Drug Information

Drug Indication：

Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer.

Pharmacology：

Data not found.

MeSH：

Chemical or physical agents that protect the skin from sunburn and erythema by absorbing or blocking ultraviolet radiation. (See all compounds classified as Sunscreening Agents.)

Absorption：

Intended for local use only, no systemic absorption.

Metabolism/Metabolites：

Intended for local use only, no systemic absorption.

Biological Half-Life：

Intended for local use only, no systemic absorption.

Mechanism of Action：

Chemical sunscreen, it acts through absorption of UVB light and not UVA.

MeSH Entry Terms：

2-ethylhexyl salicylate

2-Ethylhexyl salicylate Use and Manufacturing

Uses

Solvent for solid sunscreens.

Odor agents

Personal care products

Production

25,000 - 100,000 lb

Manufacturing Info：

Fragrances|Benzoic acid, 2-hydroxy-, 2-ethylhexyl ester: ACTIVE

Use Classification：

Cosmetics -> Uv absorber; Uv filter

Computed Properties

Molecular Weight:250.33
XLogP3:5.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:250.15689456
Monoisotopic Mass:250.15689456
Topological Polar Surface Area:46.5
Heavy Atom Count:18
Complexity:240
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Absorbs UVB radiation in the 280-320nm range, acts as a weak UVB absorber, and helps improve the photostability and efficacy of other sunscreen agents.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

BROAD SPECTRUM SPF50_SPF 50- avobenzone, homosalate octisalate,_gel
Manufacturer	NAKED SUNDAYS PTY LTD

HYDRATING SUNSCREEN MOISTURIZER BROAD SPECTRUM SPF50_SPF 50- avobenzone, homosalate octisalate,_cream
Manufacturer	NAKED SUNDAYS PTY LTD

LIGHT HEARTED BROAD SPECTRUM SPF 30 SUNSCREEN- octisalate, octocrylene, zinc oxide_lotion
Manufacturer	Sunday Riley Modern Skincare, LLC

See More Related Drugs

Registered Holders

SYMRISE INC

United States
Active
HAARMANN AND REIMER CORP

United States
Inactive

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