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Home > Encyclopedia > (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUMCHLORIDE

(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUMCHLORIDE

(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUMCHLORIDE structure

(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUMCHLORIDE 

structure
  • CAS No:

    3462-95-1

  • Formula:

    C25H21ClFP

  • Chemical Name:

    (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUMCHLORIDE

  • Synonyms:

    (4-Fluorobenzyl)triphenylphosphonium chloride;(4-fluorophenylmethyl)triphenylphosphonium chloride;Phosphonium, [(4-fluorophenyl)methyl]triphenyl-, chloride;ACMC-20a9k1;C25H21ClFP;KSC495G9T;SCHEMBL376693;CTK3J5399;KS-00000IKS;DTXSID80369940

  • Categories:

    Organic Chemistry  >  Phosphines

Description

white granular crystalline powder

(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUMCHLORIDE Basic Attributes

406.86

406.105347

4075331

DTXSID80369940

2931900090

Characteristics

0

2.32380

310-312°C

Safety Information

36/37/38

37/39-26

Xi

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

H315

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 43 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUMCHLORIDE Use and Manufacturing

General procedure: The synthesis of trans-3a is used as an example: a mixture of 4.0g (2.78mmol) of 4-fluorobenzyl chloride and 8.73g (3.30mmol) triphenylphosphine in 12mL of benzene was refluxed for 2 days to yield white solid. Collect the solid by suction filtration and (4-fluorobenzyl)-triphenylphosphonium salt was obtained in 82percent yield. Afterward, a mixture of 9.97g (2.5mmol) of the previous salt, 2.37g (2.2mmol) of benzaldehyde, and 0.82g (3.11mmol) of 18-crown-6 in 56mL of dichloromethane was stirred violently and 27mL of 50percent aqueous solution of KGeneral procedure: To a solution of substituted benzyl halide in toluene was added triphenylphosphine (1.5 eq) and the mixture was refluxed. After cooling, the precipitate was filtered to give the target compound.

Computed Properties

Molecular Weight:406.9
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:406.1053435
Monoisotopic Mass:406.1053435
Heavy Atom Count:28
Complexity:378
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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