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(-)-Phenylephrine hydrochloride

(-)-Phenylephrine hydrochloride structure

CAS No:
61-76-7
Formula:
C9H13NO2.ClH
Chemical Name:
(-)-Phenylephrine hydrochloride
Synonyms:
Benzenemethanol,3-hydroxy-α-[(methylamino)methyl]-,hydrochloride (1:1),(αR)-;Benzyl alcohol,m-hydroxy-α-[(methylamino)methyl]-,hydrochloride,(-)-;Benzenemethanol,3-hydroxy-α-[(methylamino)methyl]-,hydrochloride,(R)-;Benzenemethanol,3-hydroxy-α-[(methylamino)methyl]-,hydrochloride,(αR)-;Almefrin;(-)-α-Hydroxy-β-(methylamino)ethyl-α-(3-hydroxybenzene)hydrochloride;Isophrin hydrochloride;Neophryn;Sucraphen;Synasal;(-)-Phenylephrine hydrochloride;l-Phenylephrine hydrochloride;Metaoxedrine chloride;Levophenylephrine hydrochloride;Phenylephrine hydrochloride;l-m-Hydroxy-α-[(methylamino)methyl]benzyl alcohol hydrochloride;l-1-(m-Hydroxyphenyl)-2-methylaminoethanol hydrochloride;l-α-Hydroxy-β-methylamino-3-hydroxy-1-ethylbenzene hydrochloride;Neo-Synephrine hydrochloride;Meta-Synephrine hydrochloride;Adrianol;Meta-Sympatol;Oftalfrine;Lexatol;Metaoxedrine hydrochloride;R-(-)-m-Synephrine hydrochloride;Neo-Synesin 1;(R)-Phenylephrine hydrochloride;Mydfrin;Prefrin;Decadron;M-Sympatol;Nostril;Pyracort D;Isophrin;Alcon Efrin;Ak-Dilate;Ak-Nefrin;Neosinesine;Irifrin;R-Phenylephrine hydrochloride;(R)-3-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride;644-22-4;827-62-3;50741-76-9
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

(R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

(-)-Phenylephrine hydrochloride Basic Attributes

Molecular Weight：

203.67

Exact Mass：

203.071304

EC Number：

200-517-3

HScode：

2922509090

Characteristics

PSA：

52.49000

XLogP3：

1.83790

Appearance：

White to almost white Crystalline Powder

Melting Point：

142.5 °C

Boiling Point：

341.1ºC at 760 mmHg

Flash Point：

9℃

Refractive Index：

-45.5 ° (C=1, H2O)

Water Solubility：

>=10 g/100 mL at 21 ºC

Storage Conditions：

Desiccate at RT

Toxicity：

LD50 in rats (mg/kg): 17 ±1.1 i.p.; 33 ±2.0 s.c. (Warren, Werner)

Specific rotation：

-47 º (c=2, H2O)

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

22-36/37/38-39/23/24/25-23/24/25-11

safety instructions：

26-36-37/39-45-36/37-16-7

RTECS Number：

DO7525000

Marks：

Xn,T,F

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

(-)-Phenylephrine hydrochloride Use and Manufacturing

DECONGESTANTS

Material

Benzyl alcohol

3-Hydroxybenzaldehyde

Toluene

Drug Function and Efficacy

It can selectively shrink the capillaries in the upper respiratory tract, eliminate congestion in the nasopharyngeal mucosa, and relieve nasal congestion symptoms

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Phenylephrine hydrochloride
Manufacturer	Chifeng Arker Pharmaceutical Technology Co., Ltd.

Children's Compound Paracetamol and Renin Tablets
Ingredients	Content per tablet: Uses: Acetaminophen 125 mg analgesic, antipyretic chlorpheniramine maleate 1 mg anti-allergic vitamin B11 mg promotes carbohydrate metabolism, maintains normal function of the heart, nervous and digestive systems. Phenylephrine hydrochloride 2.5 mg nasal congestion
Indication	You should not take this medicine if you are taking or within 14 days of stopping a monoamine oxidase inhibitor (MAOI). A monoamine oxidase inhibitor (MAOI) is a type of medicine used to treat depression, mental or mood symptoms, or Parkinson's disease.

Compound Aminophenamine Capsules
Ingredients	Acetaminophen, bromhexine hydrochloride, brompheniramine maleate, caffeine, phenylephrine hydrochloride.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Compound
Manufacturer	Zhouzhi Qingqingbao Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

DIVI'S LABOTATORIES LTD

United States
Active
SHILPA PHARMA LIFESCIENCES LTD

United States
Active
AARTI PHARMALABS LTD

United States
Active

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Latest News on (-)-Phenylephrine hydrochloride

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Guide of (-)-Phenylephrine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

(-)-Phenylephrine hydrochloride

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