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4-Aminophthalhydrazide

4-Aminophthalhydrazide structure

CAS No:
3682-14-2
Formula:
C8H7N3O2
Chemical Name:
4-Aminophthalhydrazide
Synonyms:
ISOLUMINOL;IsoluMinol 4-AMINOPHTHALHYDRAZIDE;4-AMINOPHTHALOYLHYDRAZINE;6-Amino-2,3-dihydro-1,4-phthal-;4-AMINOPHTHALHYDRAZIDEMONOHYDRATE;4-AMINOPHTHALHYDRAZIDEHYDRATE,98%;Isoluminol[Chemiluminescencereagent];6-AMINO-2,3-DIHYDROPHTHALAZINE-1,4-DIONE;6-AMINO-2,3-DIHYDRO-1,4-PHTHALAZINEDIONE
Categories:
Active Pharmaceutical Ingredients > Other Chemical Drugs

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Description

Powder

4-Aminophthalhydrazide Basic Attributes

Molecular Weight：

177.16

Exact Mass：

177.053833

UNII：

5ID1912ANA

NSC Number：

13567

HScode：

2933990090

Characteristics

PSA：

84.2

XLogP3：

-0.2

Density：

1.4±0.1 g/cm3

Melting Point：

300 °C(lit.)

Boiling Point：

633°C at 760 mmHg

Flash Point：

336.7ºC

Refractive Index：

1.649

Water Solubility：

soluble in ammonium hydroxide, sodium carbonate or other base.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compound such as LUMINESCENT PROTEINS that cause or emit light (PHYSICAL LUMINESCENCE). (See all compounds classified as Luminescent Agents.)

MeSH Entry Terms：

3-aminophthalhydrazide

4-Aminophthalhydrazide Use and Manufacturing

Methods of Manufacturing

Transfer the product B to a 5 L hydrogenation vessel, add 3 g of 10 wtpercent palladium on carbon palladium, heat to 35 ° C, while the introduction of hydrogen pressure to 4atm, continue to heat constant pressure reaction 4 hours, after the end of the reaction, the hydrogen into nitrogen, Adjust the pH to 3-4 with 35 wtpercent concentrated hydrochloric acid, continue heating to 100 ° C, stop the introduction of nitrogen, filter hot, and cool the filtrate to HTC, a large number of precipitated precipitation, precipitate out completely after the filter, the filtrate for organic solvent recovery, filter cake with 400ml deionized water washing, drying, to be 214g isluminolide (4-amino phthalide)Under stirring at room temperature, in a step upward reaction to the 10g sodium thiosulfate, after stirring at room temperature for 30 minutes. Then heating reflux reaction 3 hours, confirming board 4-nitrosodi phthalic hydrazide has been fully converted to the required products, to stop the reaction, the reaction liquid natural cooling down to room temperature, then filtered, collecting filter cake. Filtrate the spin vaporization recovery 95percent ethanol, the residue combined with the filter cake, is added to the 200 ml water, heating to 80 °C, stirring 30 minutes, there are still some solid insoluble, filter when it is hot. In the filtrate by adding concentrated hydrochloric acid to adjust pH to 9, natural cooling crystallization. Filtering, receive 26g strawcoloured powdered products.

Uses

Chemiluminescence reagent

Computed Properties

Molecular Weight:177.16
XLogP3:-0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Exact Mass:177.053826475
Monoisotopic Mass:177.053826475
Topological Polar Surface Area:84.2
Heavy Atom Count:13
Complexity:254
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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