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3-Amino-4-methylpyridine

3-Amino-4-methylpyridine structure

CAS No:
3430-27-1
Formula:
C6H8N2
Chemical Name:
3-Amino-4-methylpyridine
Synonyms:
3-Pyridinamine,4-methyl-;4-Picoline,3-amino-;4-Methyl-3-pyridinamine;3-Amino-4-methylpyridine;3-Amino-4-picoline;3-Amino-γ-picoline;Ampic;4-Methylpyridin-3-ylamine
Categories:
Pharmaceutical Intermediates > Immunological Agents

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Description

White to brown crystal or powder

3-Amino-4-methylpyridine Basic Attributes

Molecular Weight：

108.14

Exact Mass：

108.14

BRN：

107792

EC Number：

-0

UNII：

9HN55RQ07B

DSSTox ID：

DTXSID20187867

HScode：

29333990

Characteristics

PSA：

38.9

XLogP3：

0.5

Density：

1.0275 (estimate)

Melting Point：

104-105 °C

Boiling Point：

254°C

Flash Point：

254°C

Refractive Index：

1.574

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

2811

wgk germany：

hazard class code：

23/24/25-36/37/38-41-37/38-22-20/21/22

safety instructions：

26-36/37/39-45-36

Marks：

T,Xn

Hazard note：

Toxic

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P310, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (13.33%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

3-amino-4-picoline

3-Amino-4-methylpyridine Use and Manufacturing

4-Methyl-3-nitropyridine (3.642 g, 26.37 mmol; Lancaster) in ethyl acetate (36 mL) was treated with 10percent Pd/C (0.25 g) under a hydrogen atmosphere (60 psi) for 30 minutes. The catalyst was removed by filtration and the solution was concentrated to provide the title product as a white solid (2.92 g, 100percent). MS (DCI/NH3) m/z 109 (M+H)+.High pressure reactor was added 300 mL of methanol, 150 g of 3-bromo-4-methylpyridine, 5g copper sulfate, pass ammonia to a pressure of 5 atm, heated to 160 ° C, reacted for 8 h, Cooled, filtered and the filtrate was concentrated under reduced pressure to give a solid which was recrystallized from ethyl acetate to give 89 g of 3-amino-4-methylpyridine in a yield of 95percent.EXAMPLE 39A

Computed Properties

Molecular Weight:108.14
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:108.068748264
Monoisotopic Mass:108.068748264
Topological Polar Surface Area:38.9
Heavy Atom Count:8
Complexity:72.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3-Amino-4-methylpyridine

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

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3-Amino-4-methylpyridine 99% powder to crystal Dideu

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Content: 99%

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