1-(Methylamino)adamantane
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1-(Methylamino)adamantane
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CAS No:
3717-38-2
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Formula:
C11H19N
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Chemical Name:
1-(Methylamino)adamantane
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Synonyms:
Tricyclo[3.3.1.13,7]decan-1-amine,N-methyl-;1-Adamantanamine,N-methyl-;N-Methyltricyclo[3.3.1.13,7]decan-1-amine;1-(Methylamino)adamantane;N-Methyl-1-adamantylamine;N-Methyladamantine;N-Methyladamantanamine;N-(1-Adamantyl)-N-methylamine;MRZ 2/188;N-Methyl-1-adamantanamine
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CAS No:
Safety Information
NONH for all modes of transport
3
26
AU4375400
Xn
P261-P305 + P351 + P338
H302-H315-H319-H335
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1-(Methylamino)adamantane Use and Manufacturing
1) In a glove box, 0.25 mmol of amantadine, 6 equiv (1.5 mmol) of diphenylsilane, 10 molpercent (based on amantadine) Cesium carbonate, 1.6 ml of acetonitrile solvent was added to 50 ml of a Schlenk tube protected with N2. To a volume of 50 mL of Hastelloy autoclave was placed 10 mL of solvent n-hexane, 1 mmol of amantadine, A certain amount of Au / Al2O3 catalyst (containing 5μmol)The autoclave was sealed and the inside of the autoclave was replaced with nitrogen three times, And then into the 1MPa of CO2 gas and 3MPa of H2, Keep the kettle gas pressure at 4MPa, Placed on the chassis with aluminum block on the magnetic stirrer, So that the temperature quickly rose to 140 , Open the magnetic stirring, Stirring at 1000 rpm for 7 hours, After cooling, add a certain amount of n-octane as the internal standard, Using gas chromatography (FID detector), N-methylamine adamantine yield was 55percentThe yield of N, N-dimethyl-amantadine was 45percentNo other byproducts are generated.6.0 mg (0.01 mmol) of complex 1 produced in Reference and 303 mg (2 mmol) of 1-adamantylamine were added to a 100 ml stainless autoclave, nitrogen substitution was conducted, and 2 ml of methanol was then added thereto.
Computed Properties
Molecular Weight:165.27
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:165.151749610
Monoisotopic Mass:165.151749610
Topological Polar Surface Area:12
Heavy Atom Count:12
Complexity:156
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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