2-CHLORO-1,3-BENZOTHIAZOLE-6-CARBOXYLICACID

To a suspension of To a mixture of To j0141J Compounds such as 17 and 18 were prepared as described below. To a solution of the desired carboxylic acids (e.g. compounds 15 and 16) (1.0 equiv, 0.420 mmol) and HATU (0.192 g, 0.504 mmol) in N, N-Dimethylformamide (DMF) (3 mL) at rt was added DIPEA (0.220 mL, 1.260 mmol) and the mixture was stirred for 10 minutes. To the reaction mixture was then added tert-butyl (2-(2-(2- aminoethoxy)ethoxy)ethyl)carbamate (1) (0.100 mL, 0.420 mmol) and the reaction was allowed to stir at rt overnight. The reaction was diluted with EtOAc (100 mL) and washed with NH4CI (2 X 100 mL) and saturated NaCI (1 X 50 mL). The organic layer (containing compounds 17 and 18) was dried over MgSO4 and then evaporated to dryness.

Molecular Weight:213.64
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:212.9651272
Monoisotopic Mass:212.9651272
Topological Polar Surface Area:78.4
Heavy Atom Count:13
Complexity:226
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes