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Halazone

pharmaceutical raw materials
Halazone structure

Halazone 

structure
  • CAS No:

    80-13-7

  • Formula:

    C7H5Cl2NO4S

  • Chemical Name:

    Halazone

  • Synonyms:

    Benzoic acid,4-[(dichloroamino)sulfonyl]-;Benzoic acid,p-(dichlorosulfamoyl)-;Halazone;4-[(Dichloroamino)sulfonyl]benzoic acid;p-(Dichlorosulfamoyl)benzoic acid;p-(N,N-Dichlorosulfamyl)benzoic acid;Pantocid;p-Sulfondichloramidobenzoic acid;Pantocide;Pantosid;p-(N,N-Dichlorosulfamoyl)benzoic acid;Halazon;Pentocid;Zeptabs;4-Carboxy-N,N-dichlorobenzenesulfonamide;NSC 60717

  • Categories:

    Active Pharmaceutical Ingredients  >  Synthetic Anti-infective Drugs

Description

white powder


Halazone is a fine white powder with an odor of chlorine. (NTP, 1992)


Halazone is a fine white powder with an odor of chlorine. (NTP, 1992)

Halazone Basic Attributes

270.09

270.09

201-253-1

G359OL82VB

757053|60717

1479

DTXSID9025370

2935009090

Characteristics

83.1

2.76390

Halazone is a fine white powder with an odor of chlorine. (NTP, 1992)

1.717 g/cm3

195 °C (decomp)

437ºC at 760 mmHg

218.1ºC

less than 1 mg/mL at 70° F (NTP, 1992)

Oral-Rat LD50 3500 mg/kg; intravenous-rat LD50: 300 mg/kg

Combustible, fires emit nitrogen oxides, sulfur oxides and chlorides, which irritate the smoke

Insoluble in water.

Acids, Carboxylic

Safety Information

III

5.1

1479

3

DG8050000

T+

Warehouse low temperature, ventilated, dry

Stable, but may be light sensitive. Incompatible with strong oxidizing agents.

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

H315

Flash point data for this chemical are not available, but it is probably combustible. (NTP, 1992)

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 140 [Oxidizers]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. LARGE SPILL: Consider initial downwind evacuation for at least 100 meters (330 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Toxicity

moderately toxic

Drug Information

Excerpt from ERG Guide 140 [Oxidizers]: Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

4-((dichloroamino)sulfonyl)benzoic acid

Halazone Use and Manufacturing

Uses

Water disinfectant.

Benzoic acid, 4-[(dichloroamino)sulfonyl]-: INACTIVE

Computed Properties

Molecular Weight:270.09
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:268.9316342
Monoisotopic Mass:268.9316342
Topological Polar Surface Area:83.1
Heavy Atom Count:15
Complexity:329
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

When this product comes into contact with water, it releases hypochlorous acid, and then releases free chlorine to kill bacteria. It is relatively stable, has strong bactericidal power, and lasts for a long time. It is mainly used for drinking water disinfection.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • Reyoung Pharmaceutical Co., Ltd.

    China China
    Active

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