2-(Dimethylamino)ethyl (2E)-[(1R,4aS,4bR,7S,8aR,10aS)-dodecahydro-7-hydroxy-1,4b,8,8-tetramethyl-10-oxo-2(1H)-phenanthrenylidene]acetate

405.579

405.57

PQK203C49T

GLOSSY FLAKES FROM ETHER

66.8

3.1

1.093±0.06 g/cm3(Predicted)

142.5 °C

405 °C

SOL IN METHANE, ETHANOL, ACETONE, ACETIC ACID, CHLOROFORM, ETHER, BENZENE

SPECIFIC OPTICAL ROTATION: -110.5 DEG @ 23 °C/D (ALC); -101 °C @ 23 °C/D (0.1 N HCL)

A review with approx 25 references of interaction of ouabain and cassaine with (Na-K)-dependent adenosine triphosphatase and its relation to their inotropic actions.[Tobin T, Akera T; Interaction of ouabain and cassaine with (sodium-potassium ion)-dependent ATPase and its relationship to their inotropic actions; Drug Action Mol Level (Rep Symp): 213-33 (1977)]

THE BARK OF THE AFRICAN ERYTHROPHLEUM GUINEENSE ('SASSY BARK') IS WELL KNOWN AS AN ORDEAL POISON & AN INGREDIENT OF ARROW POISONS. IT CONTAINS CASSAINE & OTHER ALKALOIDS, & HAS BEEN USED FOR MALICIOUS POISONING OF ANIMALS.

THE ERYTHROPHLEUM ALKALOID CASSAINE-HCL AND ITS METHIODINE AND ETHIODIDE EXHIBITED A POSITIVE INOTROPIC EFFECT ON STIMULATED LEFT ATRIA OF RABBITS.|Cassaine, an alkaloid of Erythrophleum guineense (Leguminosae) bark, is one of the few natural compounds that has a digitalis-like action on the heart muscle.|THE STRUCTURE-CARDIOTONIC AND TOXIC ACTIVITY RELATIONSHIP OF 20 ERYTHROPHLEUM ALKALOIDS WAS STUDIED IN ISOLATED RABBIT AND GUINEA PIGS PAPILLARY MUSCLE. THE PRESENCE OF A 3-OH GROUP INCREASED CARDIOTONIC ACTIVITY WHICH WAS FURTHER ENHANCED BY ESTERIFICATION.

THE ALKALOIDS ERYTHROPHLEINE & CASSAINE (NERVOCIDINE) ARE KNOWN TO HAVE ANESTHETIC ACTION, BUT WHEN APPLIED TO THE EYE ARE EXCESSIVELY IRRITATING & INJURIOUS TO THE CORNEA, CONJUNCTIVA, & IRIS. THESE ALKALOIDS APPLIED TO ...HUMAN EYES BY SUBCONJUNCTIVAL INJECTION ALSO LOWERED THE INTRAOCULAR PRESSURE FOR SEVERAL DAYS, PRESUMABLY BY POISONING THE AQ SECRETORY MECHANISM, BUT CHEMOSIS & CORNEAL EDEMA WERE TOO MUCH FOR ANTIGLAUCOMA THERAPEUTIC USE. ONLY SLIGHT MIOSIS WAS INDUCED.

cassaine