Clinofibrate

Clinofibrate (S-8527) is a hypelipidemic agent and a HMG-CoA reductase inhibitor.

Clinofibrate is an organic molecular entity.|Clinofibrate is a fibrate drug sold and marketed in Japan.|Clinofibrate is a fibrate derivative with antilipidemic activity. Climofibrate has its greatest effect in reducing VLDL-triglyceride levels.

265·6g intermediate III and 60. 8g of sodium hydroxide in 200ml of methanol and 1328ml of water was heated at reflux for about 30min, and then concentrated under reduced pressure, the concentrate was added 450ml of water, 500ml of methylene chloride was stirred stationary layers were separated aqueous layer was added diethyl chloride 1300ml, then a solution of concentrated hydrochloric acid ΡΗ = 1~2, the organic phase was washed with water until neutral, concentrated under reduced pressure, the residue was added ethyl acetate 2L crystallization, filtration after 2h Yang Jing, receipts 203g. Take 200g resulting solid was added to 330ml of ethyl acetate, heated clear solution was added active carbon reflux, filtration, the filtrate was added ethyl acetate at room temperature crystallization, filtration as white crystals 181g, purity of 99.81percent.

An antilipemic, used as an anti-atherosclerosis agent

Molecular Weight:468.6
XLogP3:7.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:468.25118886
Monoisotopic Mass:468.25118886
Topological Polar Surface Area:93.1
Heavy Atom Count:34
Complexity:633
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes