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Xanthinol nicotinate

Xanthinol nicotinate structure

CAS No:
437-74-1
Formula:
C13H21N5O4.C6H5NO2
Chemical Name:
Xanthinol nicotinate
Synonyms:
3-Pyridinecarboxylic acid,compd. with 3,7-dihydro-7-[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]-1,3-dimethyl-1H-purine-2,6-dione (1:1);Nicotinic acid,compd. with 7-[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]theophylline (1:1);Theophylline,7-[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]-,nicotinate;Theophylline,7-[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]-,mononicotinate (salt);1H-Purine-2,6-dione,3,7-dihydro-7-[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]-1,3-dimethyl-,mono-3-pyridinecarboxylate (salt);SK 331A;Complamin;7-[2-Hydroxy-3-[N-(2-hydroxyethyl)-N-methylamino]propyl]-1,3-dimethylxanthine pyridine-3-carboxylate;7-[2-Hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]theophylline nicotinate;7-[2-Hydroxy-3-[N-methyl-N-(2-hydroxyethyl)amino]-propyl]-theophylline nicotinate;Xanthinol niacinate;Xanthinol nicotinate;7-[3-(Methyl-2-hydroxyethylamino)-2-hydroxypropyl)]theophylline nicotinate;Complamin retard;Sadamine;Complamex;Angioamin;Contamex;Stenalgil;Teonicol;Vedrin;Xavin;Xantinol nicotinate;Landrina 300;Angiomin;NSC 113217;8076-17-3
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Contamex is a DEA Schedule IV controlled substance. Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III.|A vasodilator used in peripheral vascular disorders and insufficiency. It may cause gastric discomfort and hypotension.

Xanthinol nicotinate Basic Attributes

Molecular Weight：

434.45

Exact Mass：

434.191376

EC Number：

207-115-7

DEA Code Number：

2772

NSC Number：

113217

DSSTox ID：

DTXSID0023743

ATC Code：

C - Cardiovascular system

HScode：

2933990090

Characteristics

PSA：

152

XLogP3：

-1.50150

Appearance：

White crystalline powder

Melting Point：

180 °C

Boiling Point：

589.3°C at 760 mmHg

Flash Point：

310.2ºC

Water Solubility：

>65.2 [ug/mL]

Vapor Pressure：

9.89E-15mmHg at 25°C

Safety Information

Hazard category：

IRRITANT

wgk germany：

RTECS Number：

QT1500000

Stability/Shelf Life：

Stable at normal temperatures and pressures.

Drug Information

MeSH：

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

Complamin

DEA Controlled Substances：

Ketazolam|Anxon, Loftran, Solatran, Contamex|2772|Schedule IV - Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III.|No

Xanthinol nicotinate Use and Manufacturing

Sedative, Hypnotic

Computed Properties

Molecular Weight:434.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:434.19138257
Monoisotopic Mass:434.19138257
Topological Polar Surface Area:152
Heavy Atom Count:31
Complexity:548
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It reduces peripheral vascular resistance, increases cardiac output, reduces venous pressure, activates fibrinolysis, reduces fibrinogen levels, prevents platelet aggregation, promotes the synthesis of pyrimidine nucleosides (NAD and NADP), increases the concentration of adenine nucleosides (AMP, ADP and ATP), and finally hinders lipolysis, reducing elevated cholesterol and triglyceride levels

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Xanthinol Nicotinate Tablets
Ingredients	Xanthinol Nicotinate
Indication	The simultaneous administration of ganglion blockers (such as fensulfamethoxazole, mecamylamine, panpirdine, anxetine) and sympatholytic drugs (such as prazosin, doxamitrine, ergot alkaloids) should be avoided. The combined use of ethanol, coffee and hot drinks leads to an aggravation of the reaction, and the observed consequences are such as skin redness.
Specifications	100mg
Manufacturer	Mudanjiang Lingtai Medicdment Co., Ltd.

Xanthinol Nicotinate Tablets
Ingredients	Xanthinol Nicotinate
Indication	The simultaneous administration of ganglion blockers (such as fensulfamethoxazole, mecamylamine, panpirdine, anxetine) and sympatholytic drugs (such as prazosin, doxamitrine, ergot alkaloids) should be avoided. The combined use of ethanol, coffee and hot drinks leads to an aggravation of the reaction, and the observed consequences are such as skin redness.
Specifications	100mg
Manufacturer	Longhui Phamaceufical Co., Ltd.

Xanthinol Nicotinate Sodium Chloride Injection
Ingredients	Xanthinol Nicotinate
Indication	It should not be used simultaneously with ganglionic blockers and sympathetic anti-drugs.
Specifications	250ml: 0.3g of Xanthinol Nicotinate and 2.25g of Sodium Chloride
Manufacturer	Wuhan Hualong BIO-CHEMICAL Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Shanghai Yurui BIOTECHNOLOGY (Anyang) Pharmaceutical Co., Ltd.

China
Active
Shandong Keyuan Pharmaceutical Co., Ltd.

China
Active
Harbin Pharmaceutical Group Sanjing Mingshui Pharmaceutical Co., Ltd.

China
Active

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Xanthinol niacinate

CAS No.: 437-74-1

Grade: Pharmaceutical Grade

Content: 99%

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CN
3 YRS

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High Purity 99% Xanthinol Nicotinate 437-74-1 Wholesale Price raw Xanthinol Nicotinate powder in Stock

CAS No.: 437-74-1

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Content: 99%

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