Indirubin
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Indirubin
structure -
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CAS No:
479-41-4
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Formula:
C16H10N2O2
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Chemical Name:
Indirubin
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Synonyms:
2H-Indol-2-one,3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-;[Δ2,3′-Biindoline]-2′,3-dione;Indirubin;3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one;C.I. 73200;Indigopurpurin;Indigo red;Couroupitine B;NSC 105327;53570-83-5;396106-96-0;1199246-06-4
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CAS No:
Description
Indirubin(Couroupitine B) is a purple 3,2- bisindole and a stable isomer of indigo isolated from Indigo naturalis (Apiaceae); anti-inflammatory and anticancer activities.IC50 value:Target:in vitro: The activation of EGF receptor, known to be highly expressed in psoriatic lesions, was inhibited by indigo naturalis or indirubin. The cell proliferation and CDC25B expression of epidermal keratinocytes were induced by EGF alone and confirmed to be inhibited by indigo naturalis or indirubin [2
3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one is a member of indoles.|Indirubin is under investigation in clinical trial NCT01735864 (Dosage Determination Trial for Indigo Naturalis Extract in Oil Ointment).
Characteristics
65.4
2.93420
Reddish-violet powder
1.4±0.1 g/cm3
204-205 °C
496.6°C at 760 mmHg
207.0±28.9 °C
1.709
5.34E-10mmHg at 25°C
Safety Information
R20/21/22
S36/37
DU2995000
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)|Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS. (See all compounds classified as Coloring Agents.)
indigo red
Computed Properties
Molecular Weight:262.26
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:262.074227566
Monoisotopic Mass:262.074227566
Topological Polar Surface Area:65.4
Heavy Atom Count:20
Complexity:448
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Pharmacological action not specified
Registered Holders
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Beijing Xiehe Pharmaceutical Co., Ltd.
Active
China
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Chongqing Yaoyanyuan Pharmaceutical Co., Ltd.
Active
China
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