 Home > Encyclopedia > Curcumin

Curcumin

Curcumin structure

CAS No:
458-37-7
Formula:
C21H20O6
Chemical Name:
Curcumin
Synonyms:
1,6-Heptadiene-3,5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-,(1E,6E)-;Curcumin;1,6-Heptadiene-3,5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-,(E,E)-;(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;C.I. 75300;C.I. Natural Yellow 3;Curcuma;Haidr;Halad;Haldar;Halud;Indian Saffron;Kacha Haldi;Merita Earth;Souchet;Terra Merita;Turmeric yellow;Yellow Ginger;Yellow Root;Yo-Kin;(E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;Diferuloylmethane;E 100 (dye);E 100;trans,trans-Curcumin;Turmeric (dye);Turmeric;Natural Yellow 3;C Yellow 15;Ukon (dye);Ukon;Curcumin I;Curcumine;San-Ei Curcumine AL;San-Ei Gen Curcumine AL;NSC 32982;(E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;Jianghuangsu;Curcumin W;Colorant E 100;NanoCurc;Theracurmin;Biocurcumax;BR 213;INS 100i;Lipocurc;Natxtra;Vacurin;Cureit;Longvida;Curcumax;Kiriyasu Oil Yellow U;Theracurmin CR 011L;(E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione;Curcuma yellow;15845-47-3;33171-04-9;73729-23-4;79257-48-0;91884-86-5;2103286-06-0
Categories:
Cosmetic Ingredient > Antioxidant Ingredient

Description

Curcumin is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase ((HATs)) and also shows inhibitory effects on NF-κB and MAPKs.

Curcumin (diferuloylmethane) is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family (Zingiberaceae). It is sold as an herbal supplement, cosmetics ingredient, food flavoring and food coloring. As a food additive, its E number is E100.

Curcumin Basic Attributes

Molecular Weight：

368.38000

Exact Mass：

368.38

EC Number：

617-027-4

HScode：

2932999099

Characteristics

PSA：

96.22000

XLogP3：

3.2

Appearance：

Curcumin appears as orange-yellow needles. (NTP, 1992)

Density：

0.93

Melting Point：

183 °C

Boiling Point：

591.4ºC at 760 mmHg

Flash Point：

208.9ºC

Refractive Index：

1.4155-1.4175

Water Solubility：

H2O: Slightly soluble (hot);Very soluble in ethanol, acetic acid

Storage Conditions：

-20ºC

Vapor Pressure：

6.43E-15mmHg at 25°C

Vapor Density：

13 (vs air)

Toxicity：

LD50 orally in Rabbit: > 5000 mg/kg

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26; S36

RTECS Number：

MI5230000

Marks：

Stability/Shelf Life：

Stable, but may be light sensitive. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H315-H319-H335

Caution Statement：

P261; P305 + P351 + P338

Curcumin Use and Manufacturing

For preparing curcuma paper, ph range 8-9, in detection of boron.

Computed Properties

Molecular Weight:368.4
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:368.12598835
Monoisotopic Mass:368.12598835
Topological Polar Surface Area:93.1
Heavy Atom Count:27
Complexity:507
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Synthesis Route

22608-12-4

Material

Benzaldehyde

2-Methoxyethanol

Vanillin

Acetylacetone

Propylene Glycol

Ethanol

Downstream Products

Vanillin

Drug Function and Efficacy

Anti-inflammatory, antioxidant, inhibits multiple inflammatory mediators, activates Nrf2 pathway, enhances superoxide dismutase activity, downregulates TNF-α and IL-6, improves fatty liver and hepatitis; shows anti-proliferative effects on cancer cells, induces apoptosis and autophagy, regulates signaling pathways such as cyclin D1, CDK4, Bcl-2, and HER2; may improve depression by modulating neurotransmitters like serotonin and dopamine; promotes bile secretion and has potential hepatoprotective and lipid-lowering effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

TURMERICSOAP- turmeric soap cleanses, protects purifies skin_soap
Manufacturer	Shenzhen XiaoMai Manufacturing Co., Ltd.

FLUROX FLU- anas barbariae, astragalus, echinacea ang, hydrastis, tauroxicum, zinc phos_liquid
Manufacturer	FindCure.org

DARK SPOT LIGHTENING BAR- kojic acid bar soap dark spot lightening bar_soap
Manufacturer	Shenzhen XiaoMai Manufacturing Co., Ltd.

See More Related Drugs

Registered Holders

ASIAN HERBEX LTD

United States
Active
SUNPURE EXTRACTS PVT LTD

United States
Active

Recommended Suppliers of Curcumin

Tianjin YR ChemSpec Technology Co.,Ltd. Contact Supplier

CN
8 YRS

Business licensed

Trader Supplier of Hydroxypinacolone Retinoate 10%,Hydroxypinacolone Retinoate,Niacinamide,DL-Panthenol,Ascorbyl Tetraisopalmitate,Tetrahexyldecyl Ascorbate,Ethyl Ascorbic Acid,Magnesium Ascorbyl Phosphate(,Sodium Ascorbyl Phosphate,Ascorbyl Palmitate,Sodium Hyaluronate,Ectoine,Glutathione,Ergothioneine,Gamma Polyglutamic Acid,Sclerotium Gum,Tetrahydrocurcumin,3-Dihydroxyacetone,L-Erythrulose,Kojic Acid,Kojic Acid Dipalmitate,Bakuchiol,Resveratrol,Ferulic Acid,Cetyl-PG Hydroxyethyl Palmitamide,Alpha Arbutin,Phenylethyl Resorcinol,Diaminopyrimidine Oxide,Pyrrolidinyl Diaminopyrimidine Oxide,Piroctone Olamine,Hydroxypropyl Tetrahydropyrantriol

Plant Turmeric Root Extract Powder Organic Turmeric Curcumin Powder

Unit Price: $45-55 /KG EXW

CAS No.: 458-37-7

Grade: Cosmetics Grade

Content: 95%

Inquiry
NATURE INDUSTRIAL LIMITED Contact Supplier

HK
2 YRS

Business licensed

Trader Supplier of Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332,Orforglipron,Pharmaceutical intermediates,Aniracetam,Paraxanthine,AF710B,Clascoterone,TAK-653,PRL-8-53

Bulk Curcumin Extract from Turmeric Root for Nutraceuticals for Globe market

CAS No.: 458-37-7

Grade: Cosmetics Grade

Content: 99%

Inquiry
ChenLv Herb Extract Contact Supplier

CN
6 YRS

Business licensed Certified factory

Manufactory Supplier of Synephrine,Mucuna Pruriens extract,Maca extract,Pomegranate peel extract,Resveratrol,Epimedium leaf extract,Green tea extract,Citrus bioflavonoids,Berberine hydrochloride,hesperidin

Curcuma Longa Extract Curcumin

CAS No.: 458-37-7

Inquiry
Xi'an Donghua Biotechnology Co., Ltd Contact Supplier

CN
10 YRS

Business licensed Certified factory

Manufactory Supplier of Curcumin

Curcumin Food Grade

CAS No.: 458-37-7

Grade: Food Grade

Inquiry
Henan Guangye Natural pigment co., LTD Contact Supplier

CN
10 YRS

Business licensed Certified factory

Manufactory Supplier of Curcumin

Curcumin yellow powder

CAS No.: 458-37-7

Grade: Food Grade

Inquiry