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Cinchonidine

Cinchonidine structure

CAS No:
485-71-2
Formula:
C19H22N2O
Chemical Name:
Cinchonidine
Synonyms:
Cinchonan-9-ol,(8α,9R)-;Cinchonidine;(8α,9R)-Cinchonan-9-ol;α-Quinidine;(-)-Cinchonidine;(8S,9R)-Cinchonidine;Cinchovatine;NSC 5364;185122-81-0;402846-41-7;727732-19-6;834885-39-1;849150-57-8;887770-94-7;898814-12-5;900786-79-0;900786-82-5;911480-48-3;925701-86-6;1195256-80-4;1236363-09-9;1892629-78-5;2244812-96-0
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities[1].

Cinchonidine Basic Attributes

Molecular Weight：

294.39

Exact Mass：

294.39

BRN：

89690

EC Number：

207-622-3

HScode：

29392900

Characteristics

PSA：

36.4

XLogP3：

2.82

Appearance：

White to cream Crystalline Powder

Density：

1.22 g/cm³

Melting Point：

210.5 °C

Boiling Point：

464.5°C at 760 mmHg

Flash Point：

234.7±24.6 °C

Refractive Index：

1.652

Water Solubility：

H2O: Insoluble

Storage Conditions：

Refrigerator

Toxicity：

LD50 i.p. in rats: 206 mg/kg (Johnson, Poe); LD50 orally in quail: >316 mg/kg (Schafer)

Specific rotation：

-115 º (c=1, EtOH)

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

1544

wgk germany：

hazard class code：

20/21/22-42/43-36/37/38-20/22-48/22-43-22-63

safety instructions：

22-24/25-36/37-36-26

RTECS Number：

GD2975000

Marks：

Xn,Xi

Stability/Shelf Life：

Stable, but light-sensitive. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P280

Hazard Statements：

H302-H317-H361d-H373

Cinchonidine Use and Manufacturing

Occurs in most varieties of Cinchona

Downstream Products

Formic acid

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