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Guaiazulene

Guaiazulene structure

CAS No:
489-84-9
Formula:
C15H18
Chemical Name:
Guaiazulene
Synonyms:
Azulene,1,4-dimethyl-7-(1-methylethyl)-;Azulene,7-isopropyl-1,4-dimethyl-;1,4-Dimethyl-7-(1-methylethyl)azulene;Guaiazulene;Azulon;1,4-Dimethyl-7-isopropylazulene;Silazulon;S-Guaiazulene;3,8-Dimethyl-5-(2-propyl)azulene;7-Isopropyl-1,4-dimethylazulene;Eucazulen;Kessazulen;Purazulen;Azulen-Beris;Uroazulen;Azunol;Cuteazul;Vetivazulen;AZ 8;Vaumigan;AZ 8 Beris;NSC 4714;Guaiazulene blue;1,4-Dimethyl-7-propan-2-ylazulene;1,4-Dimethyl-7-(propan-2-yl)azulene;12040-47-0
Categories:
Cosmetic Ingredient > Perfuming

Description

Guaiazulene is present in several essential oils of medicinal and aromatic plants, with antioxidant activity. Guaiazulene has in vitro cytotoxic activity against neuron and N2a neuroblastom (N2a-NB) cells[1][2].

Solid

Guaiazulene is a sesquiterpene. It derives from a hydride of a guaiane.

Guaiazulene Basic Attributes

Molecular Weight：

198.3

Exact Mass：

198.30

BRN：

1365001

EC Number：

207-701-2

UNII：

2OZ1K9JKQC

NSC Number：

4714

DSSTox ID：

DTXSID7045996

ATC Code：

S - Sensory organs

Characteristics

PSA：

XLogP3：

4.8

Appearance：

Dark blue Low Melting Crystalline Solid

Density：

0.974 g/cm³ @ Temp: 22 °C

Melting Point：

31.5 °C

Boiling Point：

153 °C

Flash Point：

>230 °F

Refractive Index：

1.573

Water Solubility：

soluble in alcohol, water, 0.1115 mg/L @ 25°C (est).

Storage Conditions：

2-8°C

Vapor Pressure：

0.00148mmHg at 25°C

Safety Information

wgk germany：

hazard class code：

22-20/21/22

safety instructions：

36/37/39-26-22-36

RTECS Number：

CO4790000

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Drug Information

MeSH Entry Terms：

azulon

Guaiazulene Use and Manufacturing

Uses

antioxidant, inhibits lipid peroxidation inhibitor, antiinflammatory, hepatoprotectant; LD50(rat) 1550 mg/kg po

Manufacturing Info：

Azulene, 1,4-dimethyl-7-(1-methylethyl)-: ACTIVE

Use Classification：

Lipids -> Prenol Lipids [PR] -> Isoprenoids [PR01] -> C15 isoprenoids (sesquiterpenes) [PR0103]|Cosmetics -> Antimicrobial

Computed Properties

Molecular Weight:198.30
XLogP3:4.8
Rotatable Bond Count:1
Exact Mass:198.140850574
Monoisotopic Mass:198.140850574
Heavy Atom Count:15
Complexity:206
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Downstream Products

Formic acid

Acetic acid

Acetone

Drug Function and Efficacy

It has anti-inflammatory and tissue granulation regeneration effects, can promote the healing of burn wounds, and has heat protection, radiation protection, and anti-crack effects. It is used for the treatment of burns, chapped skin, frostbite, eczema, dermatitis, and the prevention of high heat radiation.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Guaiazulene Ointment
Ingredients	Guaiazulene
Indication	Not yet clear
Specifications	0.003
Manufacturer	Jiangsu Jiafu Pharmaceutical Co., Ltd.

Registered Holders

Jiangsu Jiafu Pharmaceutical Co., Ltd.

China
Active

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CAS No.: 489-84-9

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1,4-Dimethyl-7- (1-methylethyl) -Azulen / Guaiazulene CAS 489-84-9

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Guaiazulene (GZ-007) Van Aroma

CAS No.: 489-84-9

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Guide of Guaiazulene

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Downstream Products
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Guaiazulene

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