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Melarsoprol

Melarsoprol structure

CAS No:
494-79-1
Formula:
C12H15AsN6OS2
Chemical Name:
Melarsoprol
Synonyms:
1,3,2-Dithiarsolane-4-methanol,2-[4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl]-;1,3,2-Dithiarsolane-4-methanol,2-[p-[(4,6-diamino-s-triazin-2-yl)amino]phenyl]-;Benzenearsonous acid,p-[(4,6-diamino-s-triazin-2-yl)amino]dithio-,cyclic (hydroxymethyl)ethylene ester;2-[4-[(4,6-Diamino-1,3,5-triazin-2-yl)amino]phenyl]-1,3,2-dithiarsolane-4-methanol;2-[p-(4,6-Diamino-s-triazin-2-ylamino)phenyl]-1,3,2-dithiarsolane-4-methanol;2-p-(4,6-Diamino-s-triazin-2-ylamino)phenyl-4-hydroxymethyl-1,3,2-dithiarsoline;Melarsoprol;Melarsaprol;Mel B;Arsobal;3854RP;Melarsen B;Benzenearsonous acid,p-[(4,6-diamino-s-triazin-2-yl)amino]dithio-,(hydroxymethyl)ethylene ester;Arsorbal;Melarsoprol B;RP 3854;Mel B Arsobal
Categories:
Organic Chemistry > Arsenicals

Description

Melarsoprol is a member of triazines.|Melarsoprol is under investigation in clinical trial NCT00330148 (Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis).|Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.

Melarsoprol Basic Attributes

Molecular Weight：

398.335

Exact Mass：

398.34

EC Number：

207-793-4

ATC Code：

P - Antiparasitic products, insecticides and repellents

Characteristics

PSA：

174

XLogP3：

1.55110

Boiling Point：

688.4ºC at 760 mmHg

Flash Point：

370.2ºC

Safety Information

Precautionary statement(s)：

P261, P264, P270, P271, P273, P301+P310, P304+P340, P311, P321, P330, P391, P403+P233, P405, P501

Hazard Statements：

H301

Drug Information

MeSH：

Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA. (See all compounds classified as Trypanocidal Agents.)

MeSH Entry Terms：

Arsobal

Melarsoprol Use and Manufacturing

Uses

Melarsoprol is a drug used for the treatment of African trypanosomes, a sleeping sickness in humans, a disease that is typically fatal without chemotherapy.

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:398.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:397.996471
Monoisotopic Mass:397.996471
Topological Polar Surface Area:174
Heavy Atom Count:22
Complexity:353
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Melarsoprol

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

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4 YRS

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melarsoprol

CAS No.: 494-79-1

Grade: Chemical Grade

Content: 98%

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