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2-Oxazolidinone

2-Oxazolidinone structure

CAS No:
497-25-6
Formula:
C3H5NO2
Chemical Name:
2-Oxazolidinone
Synonyms:
2-Oxazolidinone;Carbamic acid,(2-hydroxyethyl)-,γ-lactone;2-Oxazolidone;1,3-Oxazolidin-2-one;2-Oxotetrahydro-1,3-oxazole;NSC 35382;NSC 38240;2-Oxo-1,3-oxazolidine
Categories:
Pharmaceutical Intermediates > Antineoplastics

Description

off-white to yellow-beige crystals or powder

Oxazolidin-2-one is an oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2. It has a role as a metabolite. It is an oxazolidinone and a carbamate ester.|Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.

2-Oxazolidinone Basic Attributes

Molecular Weight：

87.08

Exact Mass：

87.08

EC Number：

207-840-9

UNII：

Z4D49W92PP

NSC Number：

38240|35382

DSSTox ID：

DTXSID2074326

HScode：

2934999090

Characteristics

PSA：

38.3

XLogP3：

-0.3

Density：

1.50 g/cm³

Melting Point：

87-89 °C @ Solvent: Chloroform

Boiling Point：

152 °C @ Press: 0.4 Torr

Flash Point：

57.2±22.6 °C

Refractive Index：

1.548

Water Solubility：

Soluble in water.

Toxicity：

TDLo orl-mus: 1000 mg/kg:ETA BCPCA62,168,59

Safety Information

wgk germany：

hazard class code：

R22;R36;R43

safety instructions：

S26-S36/37

RTECS Number：

RQ2450000

Marks：

Xn:Harmful;

Precautionary statement(s)：

P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P333+P313, P337+P313, P363, P501

Hazard Statements：

H302

Drug Information

MeSH：

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)|Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)

MeSH Entry Terms：

1,3 Oxazolidin 2 one

2-Oxazolidinone Use and Manufacturing

Uses

As an oxazole derivative used as an antibiotic, 2-Oxazolidone is also used in the preparation of compounds with antitumor activity and as a metabolite of Furazolidone (F864100).

Manufacturing Info：

2-Oxazolidinone: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:87.08
XLogP3:-0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:87.032028402
Monoisotopic Mass:87.032028402
Topological Polar Surface Area:38.3
Heavy Atom Count:6
Complexity:71.2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 497-25-6

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2-Oxazolidone

CAS No.: 497-25-6

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