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Capsaicin

Capsaicin structure

CAS No:
404-86-4
Formula:
C18H27NO3
Chemical Name:
Capsaicin
Synonyms:
6-Nonenamide,N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-,(6E)-;Capsaicin;6-Nonenamide,8-methyl-N-vanillyl-,(E)-;6-Nonenamide,N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-,(E)-;(6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide;Capsaicine;(E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide;Ratden PE 40;Zostrix;Capsin P 50;Mioton;trans-8-Methyl-N-vanillyl-6-nonenamide;Axsain;NSC 56353;Dolenon;N-(4-Oxy-3-methoxybenzyl)-8-methyl-6-nonenamide;Togarashi Orenji;E-Capsaicin;ALGRX 4975;Capzasin-HP;NGX 4010;Adlea;Ovocap;Qutenza;Ausanil;trans-Capsaicin;Chilli Orange;(E)-8-Methyl-N-vanillyl-6-nonenamide;Capsicin;912457-62-6
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide has a mild, warm-herbaceous odor and burning, pungent taste (10 ppm). It is used in compounded flavors for sauces where the pungent note is desired. Off-White Crystalline Solid Crystalline solid, rectangular plates, or scales. Pungent odor and burning taste.

Capsaicin Basic Attributes

Molecular Weight：

305.41200

Exact Mass：

305.41

EC Number：

917-707-3

HScode：

2932999099

Characteristics

PSA：

58.56000

XLogP3：

4.18050

Appearance：

Solid

Density：

1.041g/cm3

Melting Point：

65 °C

Boiling Point：

210-220 °C @ Press: 0.01 Torr

Flash Point：

263.1ºC

Refractive Index：

1.508

Water Solubility：

H2O: insoluble ;soluble in petroleum ether. Slightly soluble in concentrated hydrochloric acid

Storage Conditions：

2-8ºC

Vapor Pressure：

1.32X10-8 mm Hg at 25 deg C (est)

Toxicity：

LD50 oral in mouse: 47200ug/kg

Odor：

Highly volatile with a pungent odor

Taste：

Burning taste detectable in 1 part in 100,000

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 2811

wgk germany：

hazard class code：

R25; R37/38; R41; R42/43

safety instructions：

S22-S26-S28-S36/39-S45

RTECS Number：

RA8530000

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311

Hazard Statements：

H301-H315-H317-H319-H334-H335

Capsaicin Use and Manufacturing

A representative lot is a 5:1 E:Z mixture. It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic. K channel blocker; multiple sclerosis therapy analgesic (topical), depletes Substance P, neurotoxic Capsaicin analogue (C175680). It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic. Capsaicin is used in many topical ointments used to relieve the pain of peripheral neuropathy (treatment of pain in the nerve endings near the surface of the skin). As a tool in neurobiological research.

Computed Properties

Molecular Weight:305.4
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:9
Exact Mass:305.19909372
Monoisotopic Mass:305.19909372
Topological Polar Surface Area:58.6
Heavy Atom Count:22
Complexity:341
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Tetrahydrofuran

Vanillin

Sodium hydroxide

Hydroxylamine hydrochloride

Hydrochloric acid

Thionyl chloride

Drug Function and Efficacy

It has analgesic and antipruritic effects by affecting the release, synthesis and storage of the neurotransmitter substance P on C-type sensory neurons. Topical capsaicin acts on peripheral nerve axons, resulting in a decrease in substance P from all neurons (peripheral and central), thereby achieving analgesic effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Capsaicin Gel
Ingredients	The main ingredient of this product is capsaicin, and its chemical name is: (trans)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide.
Indication	There are no reports of interactions with other drugs during use. If you are using other medicines, please consult your physician or pharmacist before using this product.
Manufacturer	Shandong Luye Pharmaceutical Co., Ltd.

Capsaicin
Manufacturer	Shandong Luye Pharmaceutical Co., Ltd.

Capsaicin Cream
Ingredients	The main ingredient of this product is capsaicin, and its chemical name is: (trans)-N-[(4-hydroxy-3-methoxyphenyl)-methyl]-8-methyl-6-nonenylamide.
Indication	1. There are no reports of interactions with other drugs during the use of this product. 2. If you are using other medicines, please consult a physician or pharmacist before using this product.
Specifications	10g:2.5mg
Manufacturer	Changchun Puhua Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

AUDI PHARMA INGREDIENTS

United States
Active
CHILLIES EXPORT HOUSE LTD

India
Active
Shandong Luye Pharmaceutical Co., Ltd.

China
Active

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Guide of Capsaicin

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Capsaicin

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