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Neomycin B sulfate

pharmaceutical raw materials
Neomycin B sulfate structure

Neomycin B sulfate 

structure
  • CAS No:

    4146-30-9

  • Formula:

    C23H46N6O13.3H2O4S

  • Chemical Name:

    Neomycin B sulfate

  • Synonyms:

    D-Streptamine,O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-,sulfate (1:3);Neomycin B,sulfate (1:3) (salt);D-Streptamine,O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-,sulfate (1:3) (salt);Neomycin B sulfate;Neomycin B trisulfate

  • Categories:

    Analytical Chemistry  >  Standard

Description

White or yellowish-white powder, hygroscopic.


Neomycin B sulfate is the aminoglycoside sulfate salt that is the sulfate salt of neomycin B; a component of neomycin sulfate. It contains a framycetin.|Aminoglycoside antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C, and acts by inhibiting translation during protein synthesis.

Neomycin B sulfate Basic Attributes

712.72

712.28000

223-969-3

DTXSID4041074

Characteristics

436.09000

927.1ºC at 760 mmHg

514.5ºC

Safety Information

Not Classified| |Danger|H317 (99.15%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P201, P202, P260, P261, P271, P272, P273, P280, P281, P285, P302+P352, P304+P340, P304+P341, P308+P313, P312, P314, P321, P333+P313, P342+P311, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 355 companies from 25 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H302 (16.67%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P281, P301+P312, P304+P312, P304+P340, P308+P313, P312, P314, P330, P405, and P501|Aggregated GHS information provided by 12 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)

Antibiotic 10676|Fradiomycin Sulfate

Neomycin B sulfate Use and Manufacturing

Uses

Antibacterial

Neomycin, sulfate (salt): ACTIVE

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:712.7
Hydrogen Bond Donor Count:15
Hydrogen Bond Acceptor Count:23
Rotatable Bond Count:9
Exact Mass:712.27966526
Monoisotopic Mass:712.27966526
Topological Polar Surface Area:436
Heavy Atom Count:47
Complexity:953
Defined Atom Stereocenter Count:19
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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