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2-(Bromomethyl)-1,3-dioxolane

2-(Bromomethyl)-1,3-dioxolane structure

CAS No:
4360-63-8
Formula:
C4H7BrO2
Chemical Name:
2-(Bromomethyl)-1,3-dioxolane
Synonyms:
1,3-Dioxolane,2-(bromomethyl)-;Acetaldehyde,bromo-,cyclic ethylene acetal;2-(Bromomethyl)-1,3-dioxolane;Bromoacetaldehyde ethylene acetal;Bromoacetaldehyde ethylene ketal;2-Bromomethyldioxolane;Bromoacetaldehyde ethylene glycol acetal;2-(2-Bromomethyl)-1,3-dioxolane;(1,3-Dioxolan-2-yl)methyl bromide
Categories:
Pharmaceutical Intermediates > Cardiovascular Agents

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Description

clear colorless liquid

2-(Bromomethyl)-1,3-dioxolane Basic Attributes

Molecular Weight：

167

Exact Mass：

167.00

BRN：

103309

EC Number：

224-443-6

DSSTox ID：

DTXSID1063431

HScode：

2932999099

Characteristics

PSA：

18.5

XLogP3：

0.6

Appearance：

Clear colorless Liquid

Density：

1.6172 g/cm³ @ Temp: 20 °C

Boiling Point：

79 °C @ Press: 22 Torr

Flash Point：

145 °F

Refractive Index：

1.473

Water Solubility：

Immiscible with water.

Storage Conditions：

Store below +30°C.

Safety Information

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-24/25

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2-(Bromomethyl)-1,3-dioxolane Use and Manufacturing

Methods of Manufacturing

To a reaction vessel, 10.326kg (166.3mol) of ethylene glycol was added with 3.66 Kg (83.185mol) of freshly distilled acetaldehyde and stirred slowly at room temperature for 30 mins. 14.622 Kg (91.504 mol) of bromine was added dropwise, after the dropwise addition, the reaction was carried out at 0-3°C for 3.5h, and the fraction was distilled under reduced pressure. The fractions (3.6 kPa) and 11.002 Kg (65.883 mol) of 80-82 ° C were collected and identified as bromoacetaldehyde ethylene glycol, the yield is 79.2percent, the content is more than 95percent.Take 20g bromoacetaldehyde dimethyl acetal, 20g ethylene glycol, 3.5g potassium hydrogen sulfate, add 120mL anisole, the temperature increased to 140 ° C for the reaction until the bromoacetaldehyde dimethyl acetal basic reaction is complete, stop Heating, cooling, vacuum distillation, the intermediate bromoacetaldehyde ethylene glycol.The mass of bromoacetaldehyde ethylene glycol was 15 g.

Manufacturing Info：

1,3-Dioxolane, 2-(bromomethyl)-: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:167.00
XLogP3:0.6
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:165.96294
Monoisotopic Mass:165.96294
Topological Polar Surface Area:18.5
Heavy Atom Count:7
Complexity:51.7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-(Bromomethyl)-1,3-dioxolane

Hangzhou Zentra Bio-Chemical Co., Ltd. Contact Supplier

CN
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2-Bromomethyl-1,3-dioxolane 4360-63-8

CAS No.: 4360-63-8

Grade: Pharmaceutical Grade

Content: 99%

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

2-Bromomethyl-1,3-dioxolane

CAS No.: 4360-63-8

Content: 99.00%

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Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

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2-Bromomethyl-1,3-dioxolane 99% white powder kanbei

CAS No.: 4360-63-8

Grade: Industrial Grade

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AAREY DRUGS AND PHARMACEUTICALS LTD Contact Supplier

IN
4 YRS

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Manufactory Supplier of Mono Methyl Urea ( N-methyl Urea),Nimesulide,Mefenamic acid,Lumefantrine,Oxcarbazepine,Carbamazepine,Albendazole,Doxofylline

2- Bromomethyl 1,3-dioxolane (BMD) - Aarey Drugs and pharmaceuticals Ltd

CAS No.: 4360-63-8

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Guide of 2-(Bromomethyl)-1,3-dioxolane

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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2-(Bromomethyl)-1,3-dioxolane

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