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Nifuratel

Nifuratel structure

CAS No:
4936-47-4
Formula:
C10H11N3O5S
Chemical Name:
Nifuratel
Synonyms:
2-Oxazolidinone,5-[(methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-;2-Oxazolidinone,5-[(methylthio)methyl]-3-[(5-nitrofurfurylidene)amino]-;5-[(Methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone;Macmiror;Magmilor;Methylmercadone;5-[(Methylthio)methyl]-3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone;Nifuratel;3-[(5-Nitro-2-furfurylidene)amino]-5-[(methylthio)methyl]-2-oxazolidinone;Polmiror;5-(Methylmercaptomethyl)-3-(5-nitro-2-furfurylidenamino)-2-oxazolidinone;Omnes;Tydantil;5-(Methylthiomethyl)-3-(5-nitro-2-furfurylidenamino)oxazolidin-2-one;NF 113;SAP 113;Inimur
Categories:
Organic Chemistry > Nitro Compounds

Description

Nifuratel(NF 113, SAP 113) is a broad antibacterial spectrum agent, which is used as an antibacterial, antifungal, and antiprotozoal (Trichomonas).IC50 Value: 0.125-1 μg/mL(MIC, A. vaginae) [1]Target: Antibacterial; Antiprotozoal in vitro: In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 μg/mL; it is active against G. vaginalis and does not affect lactobacilli [1].in vivo: Patients were randomized to receive a 2-week course of bismuth subcitrat

Local antiprotozoal and antifungal agent that may also be given orally.

Nifuratel Basic Attributes

Molecular Weight：

285.28

Exact Mass：

285.28

EC Number：

225-576-2

ATC Code：

G - Genito urinary system and sex hormones

HScode：

29321900

Characteristics

PSA：

126.16000

XLogP3：

0.27

Appearance：

fresh yellow crystalline or yellow powder

Density：

1.6±0.1 g/cm3

Melting Point：

182 °C

Boiling Point：

423.6±53.0 °C at 760 mmHg

Flash Point：

210.0±30.9 °C

Refractive Index：

1.666

Storage Conditions：

-20°C Freezer

Toxicity：

LD50 oral in mouse: > 4500mg/kg

Safety Information

wgk germany：

hazard class code：

safety instructions：

36/37

Marks：

Drug Information

MeSH：

Agents used to treat trichomonas infections. (See all compounds classified as Antitrichomonal Agents.)|Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

MeSH Entry Terms：

Inimur

Nifuratel Use and Manufacturing

Nifuratel is a drug used as an antibacterial, antifungal, antiprotozoal (Trichomonas). Nifuratel appears to have a broad antibacterial spectrum of action and is effective against Chlamydia trachomatis and Mycoplasma spp. as well as fungal infections from Candida spp.

Computed Properties

Molecular Weight:285.28
XLogP3:0.7
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:285.04194163
Monoisotopic Mass:285.04194163
Topological Polar Surface Area:126
Heavy Atom Count:19
Complexity:386
Undefined Atom Stereocenter Count:1
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

No specific pharmacological effects mentioned

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Nifuratel vaginal tablets
Specifications	250mg/tablet

Nifuratel
Manufacturer	Beijing Jinchengtaier Pharmaceutical Co., Ltd.

Nifuratel Nystatin Vaginal Soft Capsules
Ingredients	This product is a compound preparation. Each capsule contains 500 mg of nifuratel and 200,000 units of nystatin. Class A excipients are: the contents contain vaseline, soybean oil, and ethylparaben, and the capsule shell contains gelatin, glycerin, water, sunset yellow, and titanium dioxide.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Nifuratel 500 mg and nystatin 200,000 units.
Manufacturer	Beijing Jinchengtaier Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Sichuan Mol Biopharma Co., Ltd.

China
Active
Yantai Luyin Pharmaceutical Co., Ltd.

China
Active
Shandong Luoxin Pharmaceutical Group HENGXIN Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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