5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one
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5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one
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CAS No:
4803-74-1
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Formula:
C17H15NO3
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Chemical Name:
5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one
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Synonyms:
5,6-DIMETHOXY-2-(PYRIDINE-4-YL)METHYLENE-INDAN-1-ONE;5,6-dimethoxyl-2-(piperidin-4-y)methylene-indan-1-one;5,6-DIMETHOXY-2-(4-PYRIDYLMETHYLENE)-1-INDANONE,98.0+%;2,3-dihydro-5,6-dimethoxy-2-(4-pyridinylmethylene)-1h-inden-1-one;1H-Inden-1-one,2,3-dihydro-5,6-diMethoxy-2-(4-pyridinylMethylene)-;5,6-DiMethoxy-2-(pyridin-4-ylMethylene)-2,3-dihydro-1H-inden-1-one;5,6-Dimethoxy-2-(4-pyridylmethylene)-1-indanone(DonepezilImpurity);5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one2,3-Dihydro-5,6-dim
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CAS No:
5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one Basic Attributes
281.31
281.105194
1312995-182-4
DTXSID30468795
5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one Use and Manufacturing
Process for preparation of 5, 6-dimethoxy-2-(4-pyridylmethylene)-l- indanone of formula IVTo a 1 liter round bottom flask equipped with a mechanical stirrer, thermometer pocket, addition funnel and a condenser, charged demineralized water (250ml), 5, 6- dimethoxy-l-indanone (25g) and pyridine-4-carboxaldehyde (19.5g). The reaction mixture was stirred for 5 minutes at a temperature of 25°C to 30°C. To the reaction mixture then charged a solution of potassium hydroxide (5.2g) dissolved in demineralized water (125ml) slowly over period of 2 hours at a temperature of 25 °C to 30°C. The reaction mixture was further maintained at a temperature of 25°C to 30°C for 1 hour to obtain the product, 5, 6-dimethoxy-2-(4-pyridylmethylene)-l- indanone. The product obtained was then filtered and washed with demineralized water. Dry the product under vacuum at a temperature of 50°C to 55°C for 10 hours. Yield: 98percentPurity: 99.71percent5, 6 Dimethoxy indanone (100 grams), Pyridine-4-carboxaldehyde (78.0 grams) and p-toluene sulfonic acid (138.4 grams) were suspended in toluene (1250 ml) and heated to reflux using water separator for 6 hours. The resulting mass was cooled to 25-40° C. and the solid was filtered off under suction. Further the wet solid was suspended in aqueous 10percent sodium carbonate solution (1200 ml) and stirred for 30-60 minutes. The resulting pale yellow precipitate solid was filtered off under suction, washed with water (1000 ml) and dried at a temperature of 80° C. to afford 5, 6 Dimethoxy-2-(pyridin-4yl)-methylene-indan-lone (Weight: 140 grams, 95.8percent).
An impurity of Donepezil.
Computed Properties
Molecular Weight:281.30
XLogP3:2.7
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:281.10519334
Monoisotopic Mass:281.10519334
Topological Polar Surface Area:48.4
Heavy Atom Count:21
Complexity:414
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one
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