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Matrine

Matrine structure

CAS No:
519-02-8
Formula:
C15H24N2O
Chemical Name:
Matrine
Synonyms:
1H,5H,10H-Dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one,dodecahydro-,(7aS,13aR,13bR,13cS)-;Matrine;Matridin-15-one;(7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one;(+)-Matrine;α-Matrine;NSC 146051;NSC 318810;Vegard;Bioca;Matrine-fluensulfone mixt.;569-23-3;21914-56-7
Categories:
Cosmetic Ingredient > Antioxidant Ingredient

Description

Matrine(Sophocarpidine; α-Matrine) is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and u-receptor agonist.IC50 Value: 540 μg/ml (inhibit gastric cancer cell line MNK45, MTT) [1]Target: u-receptor/kappa opioid in vitro: MTT assay showed that the matrine was able to inhibit gastric cancer cell line MNK45 in a dose-dependent manner. The concentration required for 50% inhi

Matrine is an alkaloid.

Matrine Basic Attributes

Molecular Weight：

248.36400

Exact Mass：

248.36

EC Number：

610-750-6

UNII：

N390W430AC

NSC Number：

146051

DSSTox ID：

DTXSID00274188

HScode：

1302199001

Characteristics

PSA：

23.55000

XLogP3：

1.74750

Density：

1.0888 g/cm³ @ Temp: 85 °C

Melting Point：

76 °C

Boiling Point：

233 °C @ Press: 6 Torr

Flash Point：

172.7ºC

Refractive Index：

1.536

Safety Information

wgk germany：

hazard class code：

R20/21/22

safety instructions：

S22; S26; S36/37/39; S45

Marks：

Precautionary statement(s)：

P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 42 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

matrine

Matrine Use and Manufacturing

Antifungal, nematocide Antibacterial and anti-inflammatory drugs, used to treat chronic cervicitis, bacillary dysentery, enteritis and other diseases. Diuretic effect, anti-pathogen effect

Computed Properties

Molecular Weight:248.36
XLogP3:1.6
Hydrogen Bond Acceptor Count:2
Exact Mass:248.188863393
Monoisotopic Mass:248.188863393
Topological Polar Surface Area:23.6
Heavy Atom Count:18
Complexity:356
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It can inhibit the occurrence of cachexia in tumor-bearing mice, inhibit the growth of cancer cells, and prolong the survival time of tumor-bearing mice by more than double. It can inhibit the production of cachectin in tumor cells, and also inhibit the effect of cachectin on normal cells, thus preventing cachexia in tumor patients.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Matrine Sodium Chloride Injection
Ingredients	The main ingredient of this product and its chemical name is: matrine.
Indication	Not yet clear.
Specifications	100ml: matrine 80mg and sodium chloride 0.9g

Matrine Glucose Injection
Ingredients	Matrine
Indication	Not yet clear.
Specifications	500ml: glucose 25g and matrine 150mg
Manufacturer	Changshu Leiyunshang Pharmaceutical Co., Ltd.

Matrine Sodium Chloride Injection
Ingredients	Matrine
Indication	Not yet clear.
Specifications	100ml: matrine 80mg and sodium chloride 0.9g
Manufacturer	Sichuan Pacific Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Ordos Jintuo Pharmaceutical Co., Ltd.

China
Active
Ningxia Zijinghua Pharmaceutical Co., Ltd.

China
Active
Bayannaoer Qiyuan Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Matrine

Xi'an Honest BioEngr Co.,Ltd. Contact Supplier

CN
3 YRS

Business licensed

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High-purity raw material Matrine CAS 519-02-8 at competitive pricing

CAS No.: 519-02-8

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
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CN
1 YR

Business licensed Certified factory

Manufactory Supplier of Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5,Ginsenoside Rg5,Ginsenoside Rh2,Protopanaxatriol,Epmedin C,Icariin,Icaritin,Baohuoside I,Total Ginsenosides,Total Ginsenosides from Ginseng Stems And Leaves,Oridonin,Oleuropein,Curcumin,(20)-Ginsenoside Rg3,(20)-Protopanaxadiol

Matrine

Unit Price: $20-25 /G FOB

CAS No.: 519-02-8

Grade: Industrial Grade

Content: 98%

Inquiry
Nanjing zelang Medical Technology Co., Ltd. Contact Supplier

CN
11 YRS

Business licensed Certified factory

Manufactory Supplier

Matrine 98%

CAS No.: 519-02-8

Grade: Pharmaceutical Grade

Content: 98%

Inquiry
Shaanxi Yinuo Biological Technology Co. Ltd. Contact Supplier

CN
10 YRS

Business licensed Certified factory

Manufactory Supplier

Matrine Industrial Grade

CAS No.: 519-02-8

Grade: Industrial Grade

Inquiry
Xian ZB Biotech Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Herb Extracts,Cosmetic raw materails,API

Matrine

CAS No.: 519-02-8

Grade: Pharmaceutical grade

Content: 0.99%

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Guide of Matrine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Matrine

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