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Tetrahydrozoline hydrochloride

Tetrahydrozoline hydrochloride structure

CAS No:
522-48-5
Formula:
C13H16N2.ClH
Chemical Name:
Tetrahydrozoline hydrochloride
Synonyms:
1H-Imidazole,4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-,hydrochloride (1:1);2-Imidazoline,2-(1,2,3,4-tetrahydro-1-naphthyl)-,monohydrochloride;1H-Imidazole,4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-,monohydrochloride;2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline hydrochloride;Tyzanol hydrochloride;Tyzine hydrochloride;Visine hydrochloride;Tetrahydrozoline hydrochloride;Tyzine;Tetryzoline hydrochloride;Visine;Tizine;Yxin;Soothe;Tinarhinin;Murine Plus;Tyzanol;Vislin;2-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole hydrochloride;124638-40-0;8059-87-8;33067-94-6
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Tetrahydrozoline (hydrochloride) is a α-adrenoceptor agonist. Target: α-adrenoceptorahydrozoline is an imidazoline derivative with alpha receptor agonist activity widely available in over-the-counter topical ocular and nasal formulations. More than 1,600 cases of oral exposures are reported to United States poison centers annually (1,2). Reports of significant toxicity from tetrahydrozoline ingestion are unusual but have occured primarily in small children after unintentional ingestion (

Tetrahydrozoline hydrochloride is the hydrochloride salt of tetryzoline. It is used as a nasal decongestant. It has a role as a sympathomimetic agent, a vasoconstrictor agent and a nasal decongestant. It contains a tetryzoline(1+).

Tetrahydrozoline hydrochloride Basic Attributes

Molecular Weight：

236.74

Exact Mass：

236.108032

EC Number：

208-329-3

NSC Number：

757339

DSSTox ID：

DTXSID7045316

HScode：

2934999090

Characteristics

PSA：

24.4

XLogP3：

2.67460

Appearance：

off-white solid

Melting Point：

256-257 °C (decomp)

Boiling Point：

393.5ºC at 760 mmHg

Flash Point：

191.8ºC

Water Solubility：

H2O: freely soluble

Storage Conditions：

Refrigerator

Vapor Pressure：

6.5X10-7 mm Hg at 25 deg C (est)

Collision Cross Section：

145.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

26-36

RTECS Number：

NJ4550000

Marks：

Xn,Xi

Precautionary statement(s)：

P301 + P312 + P330-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

Drug Information

MeSH：

Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS. (See all compounds classified as Ophthalmic Solutions.)|Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)|Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)

MeSH Entry Terms：

2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline

Tetrahydrozoline hydrochloride Use and Manufacturing

Uses

An alpha agonist, causing constriction of conjunctival blood vessels.Used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.

Manufacturing Info：

1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1): ACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:236.74
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:236.1080262
Monoisotopic Mass:236.1080262
Topological Polar Surface Area:24.4
Heavy Atom Count:16
Complexity:259
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Vasoconstrictor, used to reduce redness in the eyes by constricting blood vessels in the ocular surface.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

LEADER RELIEF EYE- tetrahydrozoline hcl, zinc sulfate_solution/ drops
Manufacturer	Cardinal Health

Registered Holders

SOCIETA ITALIANA MEDICINALI SCANDICCI SIMS SRL

United States
Active
PCAS

European Union
Active
ZENTIVA KS

United States
Inactive

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Guide of Tetrahydrozoline hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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