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Diphenhydramine

Diphenhydramine structure

CAS No:
58-73-1
Formula:
C17H21NO
Chemical Name:
Diphenhydramine
Synonyms:
Ethanamine,2-(diphenylmethoxy)-N,N-dimethyl-;Ethylamine,2-(diphenylmethoxy)-N,N-dimethyl-;2-(Diphenylmethoxy)-N,N-dimethylethanamine;O-Benzhydryldimethylaminoethanol;2-(Benzhydryloxy)-N,N-dimethylethylamine;β-Dimethylaminoethanol diphenylmethyl ether;α-(2-Dimethylaminoethoxy)diphenylmethane;β-Dimethylaminoethylbenzhydrylether;Diphenhydramine;2-(Diphenylmethoxy)-N,N-dimethylethylamine;Probedryl;N-[2-(Diphenylmethoxy)ethyl]-N,N-dimethylamine;Benzhydramine;DPH;Dimedrol base;FAR 90X2;NSC 665800;N,N-Dimethyl-2-(diphenylmethoxy)ethylamine;2-Benzhydryloxy-N,N-dimethylethanamine;2-(Benzhydryloxy)-N,N-dimethylethanamine;2226543-89-9
Categories:
Active Pharmaceutical Ingredients > Antiallergic Drugs

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Description

Solid

Diphenhydramine Basic Attributes

Molecular Weight：

255.35

Exact Mass：

255.35

EC Number：

200-396-7

HScode：

2922199090

Characteristics

PSA：

12.5

XLogP3：

3.3

Appearance：

Solid

Density：

1.0±0.1 g/cm3

Melting Point：

168 °C

Boiling Point：

150-165 °C @ Press: 2.0 Torr

Flash Point：

101.5±26.0 °C

Refractive Index：

1.551

Water Solubility：

In water, 3.06X10+3 mg/L at 37 deg C

Storage Conditions：

Keep container tightly closed in a dry and well-ventilated place. /Diphenhydramine hydrochloride/

Vapor Pressure：

5.8X10-6 mm Hg at 25 deg C (est)

Toxicity：

Oral-rat LD50: 390 mg/kg; Oral-Mouse LD50: 160 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes; drug side effects: dreams, changes in psychophysiological tests

PKA：

8.98None

Safety Information

RTECS Number：

KR6825000

Storage features：

Ventilated, low temperature and dry; stored separately from food materials in warehouse

Stability/Shelf Life：

Slowly darkens on exposure to light. Stable under ordinary conditions /Diphenhydramine hydrochloride/

Precautionary statement(s)：

P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P501

Hazard Statements：

H302

Toxicity

Toxicity class：

highly toxic

Diphenhydramine Use and Manufacturing

Methods of Manufacturing

It is obtained by etherification of bisbenzyl alcohol ([91-01-0]) with chloroethanol and condensation with dimethylamine.

Uses

It is used for allergic diseases of the skin and mucous membranes and nausea and vomiting caused by boat ride.

Computed Properties

Molecular Weight:255.35
XLogP3:3.3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:255.162314293
Monoisotopic Mass:255.162314293
Topological Polar Surface Area:12.5
Heavy Atom Count:19
Complexity:211
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Antihistamine, sedative and hypnotic, enhances the effect of antitussive drugs, anti-vertigo, anti-tremor paralysis

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Diphenhydramine Hydrochloride Tablets
Ingredients	The main ingredient of this product is diphenhydramine, and its chemical name is: N, N-dimethyl-2-(diphenylmethoxy)ethylamine hydrochloride
Indication	1. This product can temporarily affect the absorption of barbiturates and sodium sulfacetamide. 2. When used together with sodium para-aminosalicylate, it can reduce the latter's blood concentration. 3. It can enhance the effect of central nervous system depressants.
Specifications	25mg
Manufacturer	Datong Liqun Pharmaceutical Co., Ltd.

Joint pain relief cream
Ingredients	Zushima, camphor, borneol, menthol, methyl salicylate, diphenhydramine, musk xylene.
Indication	If you are taking other medicines, please consult your physician or pharmacist before using this product.
Specifications	7 x 10 cm
Manufacturer	Jiangxi Ji'an Sanli Pharmaceutical Co., Ltd.

Bone Health Cream
Ingredients	Safflower, belladonna fluid extract, Corydalis yanhusuo, menthol, siler, dipsaci, diphenhydramine, cicada shell, millettia reticulata, clematis, camphor, raw aconite, borneol, methyl salicylate, dimethyl sulfoxide, aged vinegar, Polygonum multiflorum.
Indication	Drug interactions may occur if used with other drugs. Please consult your pharmacist or physician for details.
Specifications	6cm×6.5cm
Manufacturer	Inner Mongolia Keerqin Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Kinhoo Pharmaceutical Co., Ltd.

China
Active
S. S. PHARMACHEM

United States
Active
Mentholatum (CHINA) Pharmaceuticals Limited

China
Inactive

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