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Pyrilamine maleate

Pyrilamine maleate structure

CAS No:
59-33-6
Formula:
C17H23N3O.C4H4O4
Chemical Name:
Pyrilamine maleate
Synonyms:
1,2-Ethanediamine,N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-,(2Z)-2-butenedioate (1:1);Pyridine,2-[[2-(dimethylamino)ethyl](p-methoxybenzyl)amino]-,maleate (1:1);1,2-Ethanediamine,N-[(4-methoxyphenyl)methyl]-N′,N′-dimethyl-N-2-pyridinyl-,(Z)-2-butenedioate (1:1);1,2-Ethanediamine,N-[(4-methoxyphenyl)methyl]-N′,N′-dimethyl-N-2-pyridinyl-,(2Z)-2-butenedioate (1:1);AH;Anisopyradamine;Neo-Antergan maleate;Anthisan maleate;Antihist;Diaminide maleate;2-[[2-(Dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine Bimaleate;2-[(2-Dimethylaminoethyl)(p-methoxybenzyl)amino]-pyridine maleate;Mepyramine maleate;N-p-Methoxybenzyl-N′,N′-dimethyl-N-α-pyridylethylenediamine maleate;Minihist;Neoantergan maleate;Paramal;Paraminyl maleate;Pymafed;Pyra Maleate;Pyranilamine maleate;Pyraninyl;Pyranisamine maleate;Pyrilamine maleate;Renstamin;Stangen maleate;Statomin maleate;Thylogen maleate;Mepyramine hydrogen maleinate;Prefrin A;Thylogen;Histapyran;Pyramal;Parmal;Paraminyl;Antamine;Histalon;Histalet Forte;Histan;Histatex;Histavet P;Enrumay;Antisan;Stangen;Stamine;NSC 3604;5572-06-5
Categories:
Active Pharmaceutical Ingredients > Antiallergic Drugs

Description

Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor.

Pyrilamine maleate Basic Attributes

Molecular Weight：

401.46

Exact Mass：

401.19500

EC Number：

200-422-7

HScode：

2933399090

Characteristics

PSA：

103

XLogP3：

2.37020

Appearance：

Pyrilamine maleate appears as white crystals or powder. Melting point 100-101°C. Bitter saline taste. An antihistamine.

Melting Point：

100-101 °C

Boiling Point：

423.8°C at 760 mmHg

Flash Point：

210.1ºC

Water Solubility：

soluble in water at 100mg/ml

Storage Conditions：

2-8°C

Toxicity：

LD50 orally in mice: 338 mg/kg (Hunziker)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

26-36/37

RTECS Number：

UT1225000

Marks：

Stability/Shelf Life：

Stability Combustible. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

Pyrilamine maleate Use and Manufacturing

A histamine H1 receptor antagonist

Drug Function and Efficacy

Antihistamine, used to relieve symptoms of allergies such as runny nose and sneezing, and may have sedative effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Registered Holders

KESHAVA ORGANICS PVT LTD

India
Active
SUPRIYA LIFESCIENCE LIMITED

European Union
Active
Supriya Lifescience Ltd

United States
Active

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