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Nitrofurazone

Nitrofurazone structure

CAS No:
59-87-0
Formula:
C6H6N4O4
Chemical Name:
Nitrofurazone
Synonyms:
Hydrazinecarboxamide,2-[(5-nitro-2-furanyl)methylene]-;2-Furaldehyde,5-nitro-,semicarbazone;Semioxamazide,1-(5-nitrofurfurylidene)-;2-[(5-Nitro-2-furanyl)methylene]hydrazinecarboxamide;Aldomycin;Babrocid;Chemofuran;Furacycline;Furacin;Furaskin;Furesol;Nefco;NFS;Nifuzon;5-Nitro-2-furaldehyde semicarbazone;Nitrofurazone;5-Nitro-2-furfuraldehyde semicarbazone;5-Nitrofurfural semicarbazone;1-(5-Nitro-2-furfurylidene)semicarbazide;Vabrocid;Veterinary nitrofurazone;Furacilin;Furaziline;Nitrofuraldehyde semicarbazone;5-Nitro-2-furfural semicarbazone;2-Furancarboxaldehyde,5-nitro-,semicarbazone;Furacine;(5-Nitro-2-furfurylidenamino)urea;Monafuracin;Nitrofural;Amifur;Nfz mix;Nitrofuran (bactericide);Mastofuran;Alfucin;Furaldon;Otofural;5-Nitrofurazone;Nifucin;Nitrofuran;Furaplast;Furalcyn;Furacilinum;Furacoccid;Coxistat;Mammex;Furazol W;Nitrozone;Furacinetten;NSC 1602;NSC 2100;NSC 44009;FuraZin;Fura-Septin;Furaseen;Topifuran;8027-71-2;60051-85-6
Categories:
Cosmetic Ingredient > Antimicrobials

Description

Nitrofural is a bactericidal compound used as an antibiotic most commonly in the form of ointments.Target: AntibacterialNitrofurazone, a nitroaromatic drug, is a broad spectrum antibiotic which has until now been considered as activated in bacteria by nitroreductases. Its use in medicine has become less frequent as safer and more effective products have become available, and it has been discontinued in the US.Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have

Nitrofurazone Basic Attributes

Molecular Weight：

198.14

Exact Mass：

198.14

BRN：

86403

EC Number：

200-443-1

ATC Code：

D08AF01

HScode：

2934999090

Characteristics

PSA：

126

XLogP3：

0.2

Appearance：

Nitrofurazone appears as odorless pale yellow needles or yellow powder. pH (saturated aqueous solution) 6.0 - 6.5. Alkaline solutions are dark orange. (NTP, 1992)

Density：

1.7±0.1 g/cm3

Melting Point：

238 °C (decomp)

Boiling Point：

236-240 °C

Flash Point：

2 °C

Refractive Index：

1.674

Water Solubility：

H2O: <0.1 g/100 mL at 19 ºC

Storage Conditions：

2-8°C

Toxicity：

Oral-Rat LD50 590 mg/kg; Oral-Mouse LD50: 249 mg/kg

Flammability characteristics：

Combustible, the fire emits nitrogen oxides and spicy irritating smoke

Odor：

ODORLESS

Taste：

NEARLY TASTELESS BUT DEVELOPS BITTER AFTERTASTE

PH：

6.0-6.5 (SATURATED WATER SOLN)

PKA：

10None

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

22-36-20/21/22-11

safety instructions：

36-36/37-26-16

RTECS Number：

LT7700000

Marks：

Xn,F

Storage features：

Treasury is low temperature, ventilated, dry; stored separately from food raw materials

Stability/Shelf Life：

Nitrofurazone darkens slowly on exposure to light; however, discoloration does not appreciably affect the potency of the drug. Light sensitivity is greatest with low concentrations of nitrofurazone in solution. The drug is stable in solutions with a pH of 4-9. Nitrofurazone may be autoclaved with little loss of antibacterial activity. Preparations of nitrofurazone should be stored and dispensed in tight, light resistant containers, avoiding exposure at all times to direct sunlight, strong fluore

Precautionary statement(s)：

P280

Hazard Statements：

H302-H317

Toxicity

Toxicity class：

highly toxic

Nitrofurazone Use and Manufacturing

Uses

Anti-infective (topical). Antimicrobial.

Use Classification：

Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

Computed Properties

Molecular Weight:198.14
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:198.03890469
Monoisotopic Mass:198.03890469
Topological Polar Surface Area:126
Heavy Atom Count:14
Complexity:261
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Urea

Drug Function and Efficacy

Stop bleeding

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Registered Holders

MINSHENG GROUP SHAOXING PHARMACEUTICAL CO LTD

United States
Active
Suzhou NO.5 Pharmaceutical FACTORY Co., Ltd.

China
Active
Jinan JINDA Pharmaceutical Chemistry Co., Ltd.

China
Active

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