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(+)-Kavain

(+)-Kavain structure

CAS No:
500-64-1
Formula:
C14H14O3
Chemical Name:
(+)-Kavain
Synonyms:
2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-,(6R)-;2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-styryl-,(R)-;2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-(2-phenylethenyl)-,[R-(E)]-;(6R)-5,6-Dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-2H-pyran-2-one;Gonosan;Kawain;(+)-Kavain;Kavain;d-Kawain;NSC 112162;(R)-(+)-Kavain;(+)-Kawain;21282-41-7
Categories:
Biochemical Engineering > Chinese Herbs

Description

(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels[1]. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied[4].

(+)-Kavain Basic Attributes

Molecular Weight：

230.26

Exact Mass：

230.26

EC Number：

207-907-2

DSSTox ID：

DTXSID5033595

HScode：

2932999099

Characteristics

PSA：

35.5

XLogP3：

1.69

Appearance：

white, fine powder

Density：

1.2±0.1 g/cm3

Melting Point：

105.5 °C

Boiling Point：

196 °C

Flash Point：

184.6±23.3 °C

Refractive Index：

1.565

Specific rotation：

D20 +105° (abs alc)

Safety Information

hazard class code：

Marks：

Drug Information

MeSH：

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)|Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)

MeSH Entry Terms：

cavain

Computed Properties

Molecular Weight:230.26
XLogP3:2.5
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:230.094294304
Monoisotopic Mass:230.094294304
Topological Polar Surface Area:35.5
Heavy Atom Count:17
Complexity:324
Undefined Atom Stereocenter Count:1
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of (+)-Kavain

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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DL-Kavain

CAS No.: 500-64-1

Content: 99.00%

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2 YRS

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kavain (high qualified)

Unit Price: $1-1.2 /KG FOB

CAS No.: 500-64-1

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Guide of (+)-Kavain

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
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(+)-Kavain

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