N1-[(5-Chloro-2-thienyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-1,2-ethanediamine

295.829

295.83

Y6068K376I

DTXSID5074848

Liquid

2942000000

47.6

3.36470

Chlorothen is a colorless liquid. (NTP, 1992)

1.1751 g/cm³ @ Temp: 25 °C

<25 °C

155-156 °C @ Press: 1.0 Torr

201ºC

1.6100 (estimate)

Slightly soluble (NTP, 1992)

6.83E-07mmHg at 25°C

Peritoneal-mouse LD50: 105 mg/kg

Flammable, decomposes toxic chloride and nitrogen oxide gas when burning

Strong base

Crystals; freely sol in water; MP: 106 to 108 °C /Hydrochloride/|WHITE, CRYSTALLINE POWDER; USUALLY HAVING FAINT ODOR; SOLN ACID TO LITMUS /CITRATE/

Slightly water soluble (NTP, 1992).

Amines, Phosphines, and Pyridines

A base. An organosulfide and an amine. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

S26-S36-S24/25

Xi

Warehouse low temperature, ventilated, dry

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Warning and caution statements for chlorothen citrate preparations are required by regulations.|Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

Flash point data for this compound are not available, but it is probably combustible. (NTP, 1992)

Fires involving this material should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

moderately toxic

LD50 Mouse ip 105 mg/kg

Histamine H1 Antagonists|ANTIHISTAMINIC MORE EFFECTIVE & LESS TOXIC THAN TRIPELENNAMINE ... PRODUCES SLIGHTLY MORE SEDATION.|...EFFECTIVE IN...ALLERGIC RHINITIS, VASOMOTOR RHINITIS, ALLERGIC CONJUNCTIVITIS, URTICARIA & ANGIOEDEMA, ALLERGIC REACTIONS TO BLOOD & PLASMA, DERMOGRAPHISM, & AS ADJUNCTS TO CONVENTIONAL THERAPY IN ANAPHYLACTIC REACTIONS. /ANTIHISTAMINES/

SIDE EFFECTS OCCUR IN ABOUT 25% OF THOSE WHO USE IT.|SEE ANTIHISTAMINES. PERSONS...SHOULD BE ALERTED TO THEIR SEDATIVE EFFECTS & SHOULD BE CAUTIONED NOT TO DRIVE AUTOMOBILE, FLY AIRPLANE, OR OPERATE HAZARDOUS MACHINERY WHILE ON SUCH MEDICATION. /ANTIHISTAMINES/|SEDATION IS MOST COMMON...VERTIGO...RESTIVENESS, & GI DISTRESS. DERMATOLOGIC COMPLICATIONS & SKIN ERUPTIONS...LOCAL APPLICATION OR ORAL... IN FEW...CENTRAL EXCITATION...INSOMNIA & NERVOUSNESS. /ANTIHISTAMINES/

4. 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG, BETWEEN 1 TEASPOON & 1 OZ FOR 70 KG PERSON (150 LB).

SEE ANTIHISTAMINICS. THESE CMPD ARE ALL READILY ABSORBED FROM GI TRACT. /ANTIHISTAMINICS/

SYMPTOMS: Symptoms include nausea, vomiting, headache, dizziness, central nervous system depression followed by hyperactivity, gastrointestinal effects, hallucinations, convulsions and coma. ACUTE/CHRONIC HAZARDS: Toxic compound. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

chlorothen

TABLETS: 25 MG. /CITRATE/|Tagathen /Citrate/. Thenclor /Hydrochloride/.|Grade: NF /Citrate/

GLC DETERMINATION OF DRUGS USING SE-30 AS STATIONARY PHASE.|ISOCRATIC MULTI-COLUMN HPLC AS TECHNIQUE FOR QUALITATIVE ANALYSIS & ITS APPLICATION TO CHARACTERIZATION OF BASIC DRUGS USING AQUEOUS METHANOL SOLVENT.