4-Fluoro-4'-methylbenzophenone

white crystal powder

General procedure: A 25 mL reaction flask was charged with copper nanoparticles (0.1 mmol)Aryl diiodonium (0.5 mmol), Benzene boronic acid (1.5 mmol), Potassium phosphate (1.0 mmol), Potassium fluoride (0.5 mmol), pivalic acid (0.5 mmol) and polyethylene glycol-400 (2.0 g)And introducedAn atmospheric pressureCarbon monoxide.The reaction mixture was reacted at 100 ° C until the reaction was complete and cooled to room temperature, The product was isolated by column chromatography after evaporation of the solvent under reduced pressure....presented by the following formula (4) which can respectively correspond to the formula (1) can be obtained.(D) Fluorine substituted aromatic compound represented by the formula (4) corresponding to the hydroxy compound wherein X1 is a substituent of the group (a) in the formula(1):...4-phenylsulfonyl-4'-fluorodiphenylether, 2, 2'-difluorobenzophenone, 2, 3'-difluorobenzophenone, 2, 4'-difluorobenzophenone, 3, 3'-difluorobenzophenone, 3, 4'-difluorobenzophenone, 4, 4'-difluorobenzophenone,