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Melphalan

Melphalan structure

CAS No:
148-82-3
Formula:
C13H18Cl2N2O2
Chemical Name:
Melphalan
Synonyms:
L-Phenylalanine,4-[bis(2-chloroethyl)amino]-;Alanine,3-[p-[bis(2-chloroethyl)amino]phenyl]-,L-;4-[Bis(2-chloroethyl)amino]-L-phenylalanine;CB 3025;NSC 8806;Alkeran;Melphalan;L-Sarcolysin;L-Sarkolysin;L-Sarcolysine;L-Phenylalanine mustard;Phenylalanine mustard;3025CB;L-PAM;Levofalan;Levofolan;Levopholan;Alanine nitrogen mustard;Melfalan;Sarcoclorin;L-Phenylalanine mustard hydrochloride;NSC 241286;67: PN: WO2010011890 PAGE: 37 claimed protein;8057-25-8
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

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Description

Melphalan is an effective DNA alkylating agent, with potent antitumor activity.

Melphalan Basic Attributes

Molecular Weight：

305.2

Exact Mass：

305.20

EC Number：

205-726-3

HScode：

2922499990

Characteristics

PSA：

66.6

XLogP3：

0.4

Appearance：

white powder

Density：

1.3±0.1 g/cm3

Melting Point：

182-183 °C (decomp)

Boiling Point：

473.1±45.0 °C at 760 mmHg

Flash Point：

239.9±28.7 °C

Refractive Index：

1.597

Water Solubility：

H2O: <0.1 g/100 mL at 22 ºC;95% ethanol and 1 drop 6 N HCl: 0.05 g/mL, clear

Storage Conditions：

-20°C Freezer

Vapor Pressure：

3.0X10-10 mm Hg at 25 deg C (est)

Specific rotation：

D25 +7.5° (c = 1.33 in 1.0N HCl); D22 -31.5° (c = 0.67 in methanol)

Odor：

Odorless

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 2811 6.1/PG 2

wgk germany：

hazard class code：

45-46-26/27/28-63-36/38-62

safety instructions：

53-22-36/37/39-45

RTECS Number：

AY3675000

Marks：

T+

Stability/Shelf Life：

Bulk: A dried sample, stored at 60 °C for 15 days, showed about 10% decomposition as indicated by UV absorption and ionic chloride content. Solution: After 24 hours in water at 28 °C, approximately 80% decomposition was observed (TLC).

Precautionary statement(s)：

P201-P260-P264-P280-P284-P302 + P350

Hazard Statements：

H300-H310-H330-H350-H361

Melphalan Use and Manufacturing

Glucocorticoid

Computed Properties

Molecular Weight:305.20
XLogP3:-0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:304.0745332
Monoisotopic Mass:304.0745332
Topological Polar Surface Area:66.6
Heavy Atom Count:19
Complexity:265
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes