2-BENZYL-5-METHOXY-1H-BENZO[D]IMIDAZOLE

General procedure: To a stirred solution of benzene-1, 2-diamine 1 (1.85 mmol)in xylenes (10 mL) were added carboxylic acid 2 (2.77 mmol)and boric acid (0.185 mmol). The resulting solution wasrefluxed for 16 h. After cooling to room temperature, the reactionwas concentrated under reduced pressure and diluted withEtOAc (50 mL). The organic phase was washed with saturatedNaHCO3 solution (2 50 mL), dried over anhydrous Na2SO4and then concentrated under reduced pressure. The residuewas purified by silica gel flash column chromatography (elutingwith 10–15percent Ethyl acetate in hexanes) to afford the title compounds3a–y and 5.6.2.21

Molecular Weight:238.28
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:238.110613074
Monoisotopic Mass:238.110613074
Topological Polar Surface Area:37.9
Heavy Atom Count:18
Complexity:265
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes