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Prednisolone acetate

Prednisolone acetate structure

CAS No:
52-21-1
Formula:
C23H30O6
Chemical Name:
Prednisolone acetate
Synonyms:
Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-11,17-dihydroxy-,(11β)-;Pregna-1,4-diene-3,20-dione,11β,17,21-trihydroxy-,21-acetate;(11β)-21-(Acetyloxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione;Meticortelone acetate;Nisolone;Prednisolone 21-acetate;Supercortyl;11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate;Prednisolone acetate;21-Acetoxy-11β,17-dihydroxypregna-1,4-diene-3,20-dione;Prenema;Cormalone;Cortipred;Deltilen;Prediacortin;Predicort;Prednelan N;Prednidoren;Inflanefran Forte;Hydroprednisone acetate;Pred-Forte;21-(Acetoxy)-11β,17α-dihydroxypregna-1,4-diene-3,20-dione;Econopred;Predalone 50;Ak-Tate;Meticotelone acetate;Inflanefran;Pred Mild;NSC 10966;Falcon;Falcon (steroid);EconoPred Plus;Omnipred
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Prednisolone 21-acetate is an adrenal cortico hormones, with anti-inflammatory, anti-allergic and immune suppressive effects.

Prednisolone acetate Basic Attributes

Molecular Weight：

402.48

Exact Mass：

402.48

EC Number：

200-134-1

HScode：

2937210000

Characteristics

PSA：

101

XLogP3：

2.58

Appearance：

white crystalline powder

Density：

1.3±0.1 g/cm3

Melting Point：

238 °C (decomp)

Boiling Point：

579.8±50.0 °C at 760 mmHg

Flash Point：

198.4±23.6 °C

Refractive Index：

112 ° (C=1, Dioxane)

Water Solubility：

11.6mg/L(25 ºC)

Storage Conditions：

2-8°C

Specific rotation：

D25 +116° (dioxane)

Safety Information

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

25-34-11

safety instructions：

45-36/37/39-26-16

RTECS Number：

TU4152500

Marks：

T,C,F

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

Missing Phrase - N15.00950417

Hazard Statements：

H300

GHS Classification：

|Danger|H300 (42.22%): Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P264, P270, P280, P281, P301+P310, P305+P351+P338, P308+P313, P314, P321, P330, P337+P313, P405, and P501|Aggregated GHS information provided by 91 companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

MeSH Entry Terms：

pred forte

Prednisolone acetate Use and Manufacturing

glucocorticoid

Computed Properties

Molecular Weight:402.5
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:402.20423867
Monoisotopic Mass:402.20423867
Topological Polar Surface Area:101
Heavy Atom Count:29
Complexity:827
Defined Atom Stereocenter Count:6
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

No specific pharmacological effects mentioned

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Prednisolone Acetate Injection
Ingredients	Prednisolone acetate. Its chemical name is: 11b,17a,21-trihydroxypregna-1,4-diene-3,20-dione-21-acetate.
Indication	⑴ Nonsteroidal anti-inflammatory analgesics can enhance its ulcerogenic effect. ⑵ It can enhance the hepatotoxicity of acetaminophen. ⑶ When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors is prone to hypocalcemia and osteoporosis. ⑷ When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. ⑸ Long-term use with anticholinergics (such as atropine) can cause increased intraocular pressure. ⑹ Tricyclic antidepressants can aggravate the mental symptoms caused by it. ⑺ When used in combination with hypoglycemic drugs such as insulin, the dose of hypoglycemic drugs should be appropriately adjusted because it can increase blood sugar in diabetic patients. ⑻ Thyroid hormones can increase its metabolic clearance rate, so when thyroid hormones or antithyroid drugs are used in combination with it, the dose of the latter should be appropriately adjusted. ⑼ When used in combination with contraceptives or estrogen preparations, it can enhance its therapeutic effects and adverse reactions. ⑽ When used in combination with cardiac glycosides, it can increase the toxicity of digitalis and the occurrence of arrhythmias. ⑾ When used in combination with potassium-excreting diuretics, it can cause severe hypokalemia and weaken the sodium-excreting and diuretic effects of diuretics due to water and sodium retention. ⑿ When used in combination with ephedrine, it can enhance its metabolic clearance. ⒀ When used in combination with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. ⒁ It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and efficacy of isoniazid. ⒂ It can promote the metabolism of mexiletine in the body and reduce the blood concentration. ⒃ When used in combination with salicylates, it can reduce the concentration of plasma salicylate. ⒄ When used in combination with growth hormone, it can inhibit the latter's growth-promoting effect.
Specifications	5ml:0.125g
Manufacturer	HUAZHONG Pharmaceutical Co., Ltd.

Prednisolone acetate
Manufacturer	Zhejiang Xianju Pharmaceutical Co., Ltd.

Prednisolone acetate eye drops
Ingredients	Prednisolone acetate.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	10ml:100mg

See More Related Drugs

Registered Holders

ZHEJIANG XIANJU PHARMACEUTICAL CO.,LTD.

Marshall Island
Active
EUROAPI FRANCE

France
Active
SYMBIOTEC PHARMALAB PRIVATE LIMITED

India
Active

See More Registered Holders

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